{"created":"2023-06-19T07:18:50.615626+00:00","id":4453,"links":{},"metadata":{"_buckets":{"deposit":"21824e68-72e1-463b-b7f3-7616f6cdcee0"},"_deposit":{"created_by":4,"id":"4453","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4453"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00004453","sets":["17:253:317","17:253:318","17:40:280","31:181:487"]},"author_link":["19506","19508","19504","19511","19505","19507","19510","19512","19503","19509"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"206","bibliographicPageStart":"205","bibliographicVolumeNumber":"5/6","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"コーン油あるいは3,3',4,4',5-pentachlorobiphenyl(PCB!26)の1μgまたは3μg/kgを,SD系雌ラットに交配前2週間から離乳まで毎日経口投与し,得られた雌出生子を5,15及び24日齢に屠殺して卵巣を採取し,ラットのメスの出生子の卵巣におけるダイオキシン類関連分子(AhR,ARNT,CYPIA1)遺伝子,ならびに卵巣機能関連分子(FSH受容体,LH受容体,Inhibina,βA,βBBの各サブユニット,GDF-9,BMP-15,c-kit,Kit-ligand)の遺伝子発現量を定量解析した。その結果,PCB126がAhRを介して出生児の卵巣に直接影響を及ぼしていること,Inhibinの各サブユニットのmRNAが15日齢以降にPCB126の曝露量に依存して低下することが明らかになり,暴露が卵胞の正常な発育に影響している可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"The dams of the Sprague-Dawley rat were orally administered 0 (corn oil), 1, or 3μg/kg of 3,3',4,4',5-pentachlorobiphenyl (PCB-126) starting 2weeks prior to mating with intact males, with doses continuing through the gestation period and until 20days after delivery. The ovaries of the female offspring were obtained on the post-natal day 5,15 and 24, and quantitative analysis of gene expression of several factors including AhR, ARNT, CYP1A1, FSH receptor, LH receptor, Inhibin subunits (α,βA,βB), GDF-9, BMP-15, c-kit, Kit-ligand was performed by real-time PCR method. The results indicate that the vertically transferred PCB-126 directly affects the ovaries of rat offspring. Furthermore, the gene expressin of inhibins might be suppressed by PCB-126 exposure, suggesting an adverse effect of PCB-126 on follicular development.","subitem_description_type":"Other"}]},"item_12_description_18":{"attribute_name":"レポート・演題番号","attribute_value_mlt":[{"subitem_description":"麻布大学ハイテク・リサーチ・センター研究プロジェクト 研究サブ・グループ1","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"000049"},{"subitem_text_value":"000259"},{"subitem_text_value":"-"},{"subitem_text_value":"000406"},{"subitem_text_value":"-"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学生物科学総合研究所"},{"subitem_text_value":"麻布大学獣医学部"},{"subitem_text_value":"麻布大学獣医学部"},{"subitem_text_value":"財・食品薬品安全センター秦野研究所"},{"subitem_text_value":"麻布大学大学院獣医学研究科動物応用科学専攻"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"Research Institute of Biosciences, Azabu University"},{"subitem_text_value":"School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"Visiting Researcher"},{"subitem_text_value":"Research Institute of Biosciences, Azabu University"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000049"},{"subitem_text_value":"000259"},{"subitem_text_value":"-"},{"subitem_text_value":"000406"},{"subitem_text_value":"-"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"代田, 欣二"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村上, 賢"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"赤堀, 文昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"代田, 眞理子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"櫻田, 陽右"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shirota, Kinji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Masaru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akahori, Humiaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shirota, Mariko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakurada, Yosuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2002-01-01"}],"displaytype":"detail","filename":"bull_jau_vol5-6-205.pdf","filesize":[{"value":"113.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol5-6-205.pdf","url":"https://az.repo.nii.ac.jp/record/4453/files/bull_jau_vol5-6-205.pdf"},"version_id":"af6523a6-8123-4500-bbee-02eabc930d54"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Co-PCBsの次世代に及ぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Co-PCBsの次世代に及ぼす影響"},{"subitem_title":"The Effects of Exposure to Coplanar PCBs on the Progeny","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["280","317","318","487"],"pubdate":{"attribute_name":"公開日","attribute_value":"2002-01-01"},"publish_date":"2002-01-01","publish_status":"0","recid":"4453","relation_version_is_last":true,"title":["Co-PCBsの次世代に及ぼす影響"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-06-19T07:48:51.572103+00:00"}