@article{oai:az.repo.nii.ac.jp:00004443,
 author = {土屋, 亮 and 久末, 正晴 and 山田, 隆紹 and Tsuchiya, Ryo and Hisasue, Masaharu and Yamada, Takatsugu},
 journal = {麻布大学雑誌, Journal of Azabu University},
 month = {Mar},
 note = {近年,イヌの原発性IMPや免疫介在性溶血性貧血症例に対してヒトのIgG製剤の投与が試みられ,劇的な効果が得られている。この効果機序を調べるために,熱凝集イヌIgG(HAIgG)の類粒球への結合に対する,ヒトIgG製剤の阻害効果を検討した。0.5μgから4μgのHAIgGの結合に対して,それぞれ50倍濃度のヒトlgGを作用させたところ,HAIgG濃度2μg,ヒトIgGlOOμg/120μlにおいて最も強い阻害効果が認められた。
以上の結果から,イヌの免疫介在性血小板減少症に対して用いられているヒトIgG大量静注療法の効果が,IgG Fcリセプターを介した細内系食細胞による血小板貪食の競合的阻害によることが示唆された。, Human intravenous Ig has been used successfully in the treatment of immune-mediated diseases including thrombocytopenia and anemia in dogs. The inhibitive effect of human immunoglobulinG (h-IgG) on the binding of heat-aggregated IgG to canine granulocytes was investigated. Co-incubation with a 50-hold excess of h-IgG inhibited binding and the greatest effect was obtained at 100μg/120μl of h-IgG and 2μg of heat-aggregated IgG. The results obtained support the therapeutic rationale of administration of h-IgG intravenous infusion to dogs with immune-mediated diseases by demonstrating blockage of the IgG Fc receptor on cells which possess the same IgG Fc receptor as cells of the mononuclear phagocyte system., P(論文), 特集, application/pdf, FEATURE ARTICLES},
 pages = {166--168},
 title = {イヌの免疫介在性血小板減少症に対するヒトIgG大量静注療法の検討},
 volume = {5/6},
 year = {2003}
}