@article{oai:az.repo.nii.ac.jp:00004439,
 author = {岩橋, 和彦 and 吉原, 英児 and 平田, 強 and Iwahashi, Kazuhiko and Yoshihara, Eiji and Hirata, Tsuyoshi},
 journal = {麻布大学雑誌, Journal of Azabu University},
 month = {Mar},
 note = {ニコチン依存形成(喫煙行動)の要因解明の一助として,ニコチン代謝酵素CYP2A6の活性に影響する遺伝子を調べ,依存との関連を調べた結果,活性が欠損するといわれる^*4遺伝子がニコチン依存形成の負の要因である可能性が示された。また,慢性期の統合失調症においてはCD8陽性リンパ球(キラーT細胞)とCD56陽性リンパ球(NK細胞)の割合が減少していたため,ウイルス感染細胞除去などの免疫学的機能が低下している可能性が示された。, The relationship between nicotine metabolism of CYP2A6 and the smoking behavior in Japanese was investigated, and lymphocyte subsets expresessed CD4, CDS, and CD56 were measured in schizophrenic patients. The CYP2A6 genotypes were determined by the PCR method. There was a significant difference in the frequency of the CYP2A6^*4C allele which is a whoie deleted allele for the human CYP2A6 gene, between smokers and non-smokers. The frequency of the CYP2A6^*4C allele was higher in non-smokers than in smokers. In thisstudy it was suggested that CYP2A6^*4C allele may prevent the carrier from smoking behavior. On the other hand, in measurement by the flow cytometry, patients group showed significantly lower CD8-expressed and DD56-expressed ceiis. No stgnificant differences were observed for CD4-expressed cells and CD4/CD8 ratio in the patients and healthy groups, although the patients group showed higher CD4/CD8 ratio. These results indicated that immunological functions, such as virus infection cell removal, were falling since the rate of a killer T cells (CDS-expressed cells) and NK cells (CD56-expressed cells) are decreasing in the chronic schizophrenia., P(論文), 特集, application/pdf, FEATURE ARTICLES},
 pages = {154--155},
 title = {精神作用物質の依存性形成と副作用発現に関する調査研究},
 volume = {5/6},
 year = {2003}
}