{"created":"2023-06-19T07:18:49.773543+00:00","id":4434,"links":{},"metadata":{"_buckets":{"deposit":"e6977d6d-a106-4751-bd29-c25fe48742cc"},"_deposit":{"created_by":4,"id":"4434","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4434"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00004434","sets":["17:254:342","17:256:351","31:181:487"]},"author_link":["19363","19364","19361","19362"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"133","bibliographicPageStart":"132","bibliographicVolumeNumber":"5/6","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"比較的低用量PCB126胎生期曝露群のラット乳腺癌では,CYP1B1の発現が亢進することが明らかとなった。この結果は,比較的低用量PCB126胎生期曝露群のラット乳腺癌で遺伝毒性の高い4-OHE2の発現優位を示唆するものである。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"While polychorinated biphenyls (PCB) are fat-soluble environmental pollutants stored breast fatty tissue and secreted in milk;the precise evidence of breast carcinoma from exposure to PCBs remains unclear. Then we investigated the interrelation between the expression of mammary tumor cytochrome P450 1B1 (CYP1B1) and the dose-response relationship in-utero and lactational exposure of PCBs congener for dimethlbenz[a]anthracene (DMBA)-induced rat mammary carcinogenesis. Female SD rats were injected (i.g.) with 25 pg, 2.5 ng, 250 ng, 7.5 ug of 3, 3', 4, 4', 5-pentachlorobiphenyl (PCB126)/kg, or the vehicle, on days 13 to 19 post-conception. Fifty-day-old female offspring were injected (i.g.) with 20mg DMBA/kg. The expression of CYP1B1 in the mammary tumors was intensive in the 250 ng-and 2.5 ng-groups, and slight in the 7.5 ug-group, and not observed in the other groups. The present studies indicate that in-utero and lactational exposure of relatively low dose PCB reveal high level CYPIBI which metabolize the 17beta-estradiol into the 3, 4-catecholestradiol acts as a enhancing agent toward DMBA-induced rat mammary carcinogenesis.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"000073"},{"subitem_text_value":"000068"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学大学院獣医学研究科"},{"subitem_text_value":"麻布大学大学院獣医学研究科"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Veterinary Science, Azabu University"},{"subitem_text_value":"Graduate School of Veterinary Science, Azabu University"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000073"},{"subitem_text_value":"000068"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"和久井, 信"}],"nameIdentifiers":[{"nameIdentifier":"19361","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高木, 敬彦"}],"nameIdentifiers":[{"nameIdentifier":"19362","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakui, Shin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19363","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takagi, Yukihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19364","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2002-01-01"}],"displaytype":"detail","filename":"bull_jau_vol5-6-132.pdf","filesize":[{"value":"156.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol5-6-132.pdf","url":"https://az.repo.nii.ac.jp/record/4434/files/bull_jau_vol5-6-132.pdf"},"version_id":"66a47c8b-bf9b-497a-bd35-1435014ef588"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"PCB126胎生期暴露の乳腺化学発がん修飾作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PCB126胎生期暴露の乳腺化学発がん修飾作用"},{"subitem_title":"In-utero and lactational exposure of 3, 3\"4, 4', 5-pentachlorobiphenyl modulate dimethlbenz [a] anthracene-induced rat mammary carcinogenesis.","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["342","351","487"],"pubdate":{"attribute_name":"公開日","attribute_value":"2002-01-01"},"publish_date":"2002-01-01","publish_status":"0","recid":"4434","relation_version_is_last":true,"title":["PCB126胎生期暴露の乳腺化学発がん修飾作用"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-06-19T07:47:32.070821+00:00"}