@article{oai:az.repo.nii.ac.jp:00003930, author = {村上, 賢 and 森田, 英利 and 加藤, 行男 and 久松, 伸 and 服部, 正平 and 藤, 英博 and 高見, 英人 and 五十君, 靜信 and 桑原, 知巳 and 高木, 邦明 and Murakami, Masaru and Morita, Hidetoshi and Kato, Yukio and Hisamatsu, Shin and Hattori, Masahira and Toh, Hidehiro and Takami, Hideto and Igimi, Shizunobu and Kuwahara, Tomomi and Takagi, Kuniaki}, journal = {麻布大学雑誌, Journal of Azabu University}, month = {Mar}, note = {ビフィズス菌(新菌種候補を含む)とその近縁種の10菌種の全ゲノム解析を完了し,ゲノムサイズは2.0~3.2Mbの範囲であった。各菌種のシンテニーの比較では,16S rRNA遺伝子配列による系統樹の近縁関係のとおり,B. breve と B. longum および B. catenulatum と B. adolescentis の組み合せでシンテニーはほぼ同じであった。それ以外の Bifidobacterium 属間では,近縁種のゲノム比較でよく見られるX(エックス)の形になっており,ori-ter軸を対称にした組み換えが複数回あったと考えられる。, We have sequenced seven species (including new species nov.) of bifidobacteria and the related three species. Their genomic size were the range of 2.0 to 3.2 Mb. We checked the location of the homologous genes in the chromosomes of ten species to compare the genomic structure of the species. According to the synteny of all the species chromosomes, the Bifidobacterium breve and B. catenulatum genes that showed high homologies to those of B. longum and B. adolescentis were picked up and aligned in the chromosomes or both bacteria, respectively. It was similar to show the phylogenetic relationships between the genomes of sequenced ten species, inferred from 16S ribosomal RNA gene sequences. The majority of the homologous genes in the other species of bifidobacteria appear to be located in versely in the related species of bifidobacteria.It is speculated that the genome backbones of the species are related to some extent but are still distinct., P(論文), 40016759598, 特集, application/pdf, FEATURE ARTICLES}, pages = {239--241}, title = {ヒト腸内細菌のゲノム情報に基づく機能解析と生体影響 : 第1報}, volume = {17/18}, year = {2009} }