@article{oai:az.repo.nii.ac.jp:00003925, author = {川上, 泰 and Kawakami, Yasushi}, journal = {麻布大学雑誌, Journal of Azabu University}, month = {Mar}, note = {大卵裂頭条虫にもスピロメト系列糖脂質が存在することが明らかとなり,この糖脂質が擬葉目に特異的に存在することがわかった。免疫組織化学染色では,マンソン裂頭条虫と堀田裂頭条虫において反応に差が認められ,前者は成虫および幼虫とも外被に,堀田裂頭条虫では虫体全体に反応が認められた。, Glycosphingolipids (GSLs) can be expected to be involved in the mediation of host-parasite interactions, as are functioning in bacterial and viral infection. In this context, we have been studying GSLs of cestodes to elucidate underlying biochemical mechanisms of parasitism. We previously reported unique GSLs, SEGLx and GalSEGLx, from the Pseudophyllidean tapeworms (Spirometra erinaceieuropaei, Diphyllobothrium nihonkaiense, D. hottai and Diplogonoporus balaenopterae). They were characterized by a carbohydrate structure Galβ1-4Glcβ-3Gal. We proposed a term "spirometosides" for glycolipids having this core. We also found the absence of these glycolipids in Cyclophyllidean tapeworms such as Hymenolepis diminuta and Dipylidium caninum. In this study, GSLs were isolated from adults of the other Pseudophyllidean tapeworm D. macroovatum. The purified GSLs were characterized by TLC-immunostaining with AK97 and proved that D. macroovatum also has spirometosides. This finding confirms that spirometosides have a taxonomical significance, being characteristic of Pseudophyllidea. We also found the glycoprotein having sugar chain same as "spirometosides" in these worms. Immunohistochemical examination showed that AK97 stained tegment of S. erinaceieuropaei, and almost tissues of D. hottai., P(論文), 特集, application/pdf, FEATURE ARTICLES}, pages = {220--223}, title = {条虫類の糖脂質および糖夕ンパク質糖鎖解析}, volume = {17/18}, year = {2009} }