{"created":"2023-06-19T07:18:31.835099+00:00","id":3915,"links":{},"metadata":{"_buckets":{"deposit":"8f78efaa-6921-4bf6-bffc-37c09785804b"},"_deposit":{"created_by":4,"id":"3915","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3915"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00003915","sets":["17:253:319","17:257:356","17:36:211","31:181:468"]},"author_link":["17998","18003","18002","18001","18000","17999"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"179","bibliographicPageStart":"177","bibliographicVolumeNumber":"17/18","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"胎子動脈管の母体indomethacin投与による収縮から再び拡張するまでの回復過程におけるNOの関与を検討するために，indomethacinによる収縮が最も強く発現するindomethacin (1 and 10 mg/kg) 投与後3時間にNO合成酵素 (NOS) 阻害剤であるN(G)-nitro-L-arginine methyl ester (L-NAME; 50 mg/kg) を投与しその後の動脈管の変化を観察した。\n　妊娠20日の母ラットにindomethacinを投与し，その3時間後にL-NAMEを投与すると，その子の動脈管はindomethacinの投与後24時間 (L-NAMEの投与後21時間) において，対照群と比較して有意な低値を示し，動脈管は収縮していた。観察された胎子動脈管の収縮の程度は，indomethacin投与後3時間でみられた収縮とほぼ同等であり，indomethacinによる収縮が持続し再拡張過程にはないことが明らかとなった。\n　以上のとおり，胎子動脈管の母体indomethacin投与による収縮から再び拡張するまでの回復過程におおいてNOのが重要な役割を担っていることが示唆された。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"We studied the effects of N(G)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase inhibitor, on the ductus arteriosus (DA) that constricted by maternal indomethacin administration in fetal rat.\n Pregnant rats were administered indomethacin (1 and 10 mg/kg) orally 24 hr before cesarean section, and then L-NAME (50 mg/kg) was injected intraperitoneally 3 hr after indomethacin administration. The caliber of the fetal DA was studied with a whole-body freezing method.\n Indomethacin alone group showed that the fetal DA was reopened 24 h after maternal indomethacin administration. However, compared with the indomethacin alone group, L-NAME-treated group showed a significant constriction of the DA 24 h after maternal indomethacin administration.\n These results indicate that NO has a significant role in the course of reopening of the fetal DA that constricted by maternal indomethacin administration.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_24":{"attribute_name":"NII論文ID(NAID)","attribute_value_mlt":[{"subitem_description":"40016759585","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"000047"},{"subitem_text_value":"000059"},{"subitem_text_value":"000230"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学大学院獣医学研究科"},{"subitem_text_value":"麻布大学大学院獣医学研究科"},{"subitem_text_value":"麻布大学大学院獣医学研究科"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Veterinary Science，Azabu University"},{"subitem_text_value":"Graduate School of Veterinary Science，Azabu University"},{"subitem_text_value":"Graduate School of Veterinary Science，Azabu University"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000047"},{"subitem_text_value":"000059"},{"subitem_text_value":"000230"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"有嶋, 和義"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山本, 雅子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"白井, 明志"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arishima, Kazuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Masako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shirai, Mitsuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-04-17"}],"displaytype":"detail","filename":"bull_jau_vol17-18-177.pdf","filesize":[{"value":"249.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol17-18-177","url":"https://az.repo.nii.ac.jp/record/3915/files/bull_jau_vol17-18-177.pdf"},"version_id":"3b3bd7be-d715-4566-847c-2978828e7176"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラット周生期における動脈管調節因子の発現動態とその機能","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット周生期における動脈管調節因子の発現動態とその機能"},{"subitem_title":"Characterization of regulators of ductus arteriosus tone in the perinatal rat","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["211","319","356","468"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-02-21"},"publish_date":"2014-02-21","publish_status":"0","recid":"3915","relation_version_is_last":true,"title":["ラット周生期における動脈管調節因子の発現動態とその機能"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-12-19T05:59:07.837246+00:00"}