{"created":"2023-06-19T07:18:31.600621+00:00","id":3910,"links":{},"metadata":{"_buckets":{"deposit":"c7a484a3-b7ed-42f6-9220-f327090c6358"},"_deposit":{"created_by":4,"id":"3910","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3910"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00003910","sets":["17:257:356","31:181:468"]},"author_link":["17983","17982"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"162","bibliographicPageStart":"161","bibliographicVolumeNumber":"17/18","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"成体ラット精巣にはグルココルチコイド・レセプター(GR)が存在し，グルココルチコイドはGRを介してテストステロン合成を抑制していることはよく知られている。胎生期精巣にもGRが存在することから，グルココルチコイドが胎子精巣の発達および機能に何らかの影響を及ぼしている可能性が考えられる。そこで，本実験は，妊娠6日目に母体両側副腎を除去することによって，胎子精巣の機能がどのように変化するかを検討することを目的とした。\n　妊娠6日に母体ラット両側副腎を除去し(ADX群)，妊娠18，19，20及び21日目に剖検し，胎子から採血し，精巣を採取した。採取した精巣からRNAを抽出し，mRNA(StAR，P450scc，P450_17a，GR，AR)発現量を半定量的PCR法によって定量した。またRIA法を用いて血漿テストステロンおよびコルチコステロン濃度を測定した。\n　通常，胎生末期のコルチコステロンは胎齢19日に，テストステロンは胎齢18にピークとなるが，ADX群の胎齢19日のコルチコステロンのピークはピークは明瞭ではなくなり，テストステロンのピークは1日遅れていた。これに呼応するように，胎齢18日のADX群のStAR及びP450scc mRNA発現量は変化していたが，GRおよびAR mRNA発現量に変化はなかった。以上の結果から，母体由来の副腎皮質ホルモンは胎子精巣のホルモン合成に関与していることが示唆された。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"It is well known that the glucocorticoid inhibits the synthesis of testosterone in the testis of adult rats through glucocorticoid receptors(GR) in their testis. Because the fetal testis also has GR, it seems that the glucocorticoid may have an ability to influences the development of fetal testicular function. In the present study, to investigate the effect of maternal adrenocortical hormone on the development of fetal testis, pregnant mothers were adrenalectomy on day 6 of gestation. Testes from fetuses on days 18 to 21 of gestation were examined. In generally, the fetal plasma corticosterone concentration reaches to the peak on day 18, the testosterone level shows the peak on day 19. However, both the hormone levels in fetuses from adrenalectomised mothers decreased. In the adrenalectomised group, StAR and P450scc mRNA, a factor and an enzyme in the steroidogenesis procedure, expression levels changed to respond the changes of hormones, although the level of GR and AR mRNA expression did not alter. These results indicate that the maternal glucocorticoid affects the synthesis of testosterone in the fetal testis.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"000059"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学大学院獣医学研究科"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Veterinary Science, Azabu University"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000059"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山本, 雅子"}],"nameIdentifiers":[{"nameIdentifier":"17982","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Masako","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17983","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-04-17"}],"displaytype":"detail","filename":"bull_jau_vol17-18-161.pdf","filesize":[{"value":"143.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol17-18-161","url":"https://az.repo.nii.ac.jp/record/3910/files/bull_jau_vol17-18-161.pdf"},"version_id":"9c7221c5-dd51-4105-8845-07fb92560809"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"母体副腎が胎子精巣の発達に及ぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"母体副腎が胎子精巣の発達に及ぼす影響"},{"subitem_title":"Effects of maternal adrenals on development of fetal testis","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["356","468"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-02-21"},"publish_date":"2014-02-21","publish_status":"0","recid":"3910","relation_version_is_last":true,"title":["母体副腎が胎子精巣の発達に及ぼす影響"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-06-19T08:23:17.433256+00:00"}