{"created":"2023-06-19T07:18:23.483272+00:00","id":3734,"links":{},"metadata":{"_buckets":{"deposit":"2aa3676f-98f1-409f-ac8a-b69d371a766a"},"_deposit":{"created_by":4,"id":"3734","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3734"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00003734","sets":["17:36:211","17:40:288","31:181:453"]},"author_link":["17482","17478","17477","17479","17481","17480"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"11","bibliographicPageStart":"1","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"合成エストロジェンであるジエチルスチルベステロール（DES）を1.5 あるいは0.5 μ g/kg/day（DES1.5 群あるいはDES0.5群と称する）の用量で妊娠SD ラットに妊娠7 日目～ 21 日目の期間，連日皮下投与し，産子の卵巣における卵胞の成長に対してどのような影響を及ぼすかについて検討した。生後6 週のDES1.5 群において，血漿FSH 濃度，血漿LH 濃度，そ一次卵胞と二次卵胞の割合が増加し，卵巣内には多数の大きめの間質細胞の集団が出現し，これらの細胞はエストロジェン受容体α （DES と結合し，その作用を仲介する）を強く発現していた。しかし，これら卵胞成長の変化は生後15 週では観察されなくなった。以上の観察結果から，胎生期に投与された低濃度のDES は卵巣の卵胞の成長に対して促進的な作用有するが，その作用は恒久的ではないことが示唆された。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Diethylstilbestrol (DES), synthetic estrogen, was administered subcutaneously at 1.5 or 0.5 μ g/kg/day (DES 1.5 group, DES 0.5 group) to pregnant Sprague-Dawley rats daily from day 7 to 21 of gestation (day 0= mating) to investigate its effects on growth of ovarian follicles. The plasma FSH and LH concentrations and the percentages of primary and secondary ovarian follicles were higher in the DES 1.5 group at 6 weeks after birth. In the DES 1.5 group, many large interstitial cell clusters appeared in the ovaries, and these interstitial cells strongly expressed estrogen receptor α , mediating the DES effect. However these follicular percentages in the DES1.5 group were almost equal to the percentages in the control group at 15 weeks after birth. These observations indicate that prenatal exposure to a low dose of DES a promot growth of ovarian follicles, but this stimulus effect is not permanent.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_24":{"attribute_name":"NII論文ID(NAID)","attribute_value_mlt":[{"subitem_description":"40019736689","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"ORIGINAL ARTICLE","subitem_description_type":"Other"}]},"item_12_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14944/00003713","subitem_identifier_reg_type":"JaLC"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"-"},{"subitem_text_value":"000040"},{"subitem_text_value":"000047"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"西川動物病院, 麻布大学獣医学部"},{"subitem_text_value":"麻布大学獣医学部"},{"subitem_text_value":"麻布大学獣医学部"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"Nishikawa Animal Hospital, Azabu University,School of Veterinary Medicine"},{"subitem_text_value":"Azabu University,School of Veterinary Medicine"},{"subitem_text_value":"Azabu University,School of Veterinary Medicine"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"-"},{"subitem_text_value":"000040"},{"subitem_text_value":"000047"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西川, 修"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"政岡, 俊夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"有嶋, 和義"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishikawa, Osamu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masaoka, Toshio","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arishima, Kazuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-03-27"}],"displaytype":"detail","filename":"bull_jau_vol24-001.pdf","filesize":[{"value":"7.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol24-001","url":"https://az.repo.nii.ac.jp/record/3734/files/bull_jau_vol24-001.pdf"},"version_id":"e93e835a-f7dc-4771-8829-4cf2c12c82e7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Diethylstilbetrol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ovarian follicle","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Prenatal administration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"低用量Diethylstilbestrol の妊娠ラットへの投与が雌産子の卵胞の成長へ及ぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"低用量Diethylstilbestrol の妊娠ラットへの投与が雌産子の卵胞の成長へ及ぼす影響"},{"subitem_title":"Effects of maternal exposure to a low dose of diethylstilbestrol on follicular growth in the ovaries of female rat offspring.","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["211","288","453"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-03-20"},"publish_date":"2014-03-20","publish_status":"0","recid":"3734","relation_version_is_last":true,"title":["低用量Diethylstilbestrol の妊娠ラットへの投与が雌産子の卵胞の成長へ及ぼす影響"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-12-19T05:59:27.647885+00:00"}