{"created":"2023-06-19T07:18:16.638366+00:00","id":3613,"links":{},"metadata":{"_buckets":{"deposit":"8e6b0f41-1596-45b3-b530-10cec4efaaae"},"_deposit":{"created_by":4,"id":"3613","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3613"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00003613","sets":["17:236:245","17:38:264","17:40:280","17:40:281","31:181:450"]},"author_link":["17175","17176","17171","17169","17173","17158","17161","17165","17163","17160","17177","17157","17167","17170","17168","17178","17159","17172","17164","17174","17166","17162"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"123","bibliographicPageStart":"121","bibliographicVolumeNumber":"19/20","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は， ヒト消化管からの分離株であるL. rhamnosus ATCC 53103 株（別名としてGG 株）のゲノムを配列決定した。ATCC 53103 株は，最もプロバイオティクス効果の研究されている菌株の1 つである。本菌株のゲノムサイズは，3.0 Mb の染色体を有し，2,836 のタンパク質をコードしていた。糖代謝・アミノ酸代謝とその輸送に関係するタンパク質の他に，注目に値する防衛機構に関する遺伝子を多く保有していた。比較のゲノム分析で，広範囲なシンテニーがL. rhamnosus ATCC 53103 株とその近縁種であるL. casei ATCC 334 株（チーズ分離株）の間でみられた。しかし，L. rhamnosus ゲノムには多数の挿入，すなわち，PTS-タイプ輸送機システム，配糖体ヒドロラーゼと転写制御因子のために遺伝子から成る遺伝子群を含み，腸環境への潜在的適合性を反映していた。ATCC 53103 株には多くの細胞表面付着タンパク質が予測された。さらに，そのゲノムは，付着性に対して機能的なSpaCBA 線毛をコード化していた。L. rhamnosus ゲノムのこれらの特徴は，消化管生存に関与して，腸の粘膜と微生物叢との相互作用に貢献していると推察された。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"We sequenced and analyzed the genome of Lactobacillus rhamnosus ATCC 53103 (also known as L. rhamnosus GG), a human isolate, which is one of the most studied probiotic strains. The organism harbored a 3.0-Mb chromosome encoding 2,836 protein-coding genes, and contained a remarkable number of proteins involved in carbohydrate and amino acid metabolism and transport, and defense mechanisms compared with other sequenced intestinal lactobacilli. Comparative genome analysis revealed that extensive synteny was found between L. rhamnosus ATCC 53103 and its closely related L. casei ATCC 334 (a cheese isolate), but the L. rhamnosus genome contains numerous insertions, which reflect potential adaptation to the gut environment, including six carbohydrate utilization gene clusters that consist of the genes for PTS-type transporter system, glycoside hydrolase, and transcriptional regulator. Genome analysis also predicted many cell surface adherence proteins, and its genome encodes functional SpaCBA pili shed on the importance of adhesion to mucus during colonization of the human. Collectively, these features in the L. rhamnosus genome are likely to contribute to the organisms’ gastric survival and promote interactions with the intestinal mucosa and microbiota.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_24":{"attribute_name":"NII論文ID(NAID)","attribute_value_mlt":[{"subitem_description":"40017293230","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"000259"},{"subitem_text_value":"000247"},{"subitem_text_value":"000075"},{"subitem_text_value":"000129"},{"subitem_text_value":"-"},{"subitem_text_value":"-"},{"subitem_text_value":"-"},{"subitem_text_value":"-"},{"subitem_text_value":"-"},{"subitem_text_value":"-"},{"subitem_text_value":"-"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学獣医学部"},{"subitem_text_value":"麻布大学獣医学部"},{"subitem_text_value":"麻布大学獣医学部"},{"subitem_text_value":"麻布大学獣医学部"},{"subitem_text_value":"東京大学大学院"},{"subitem_text_value":"理研GSC"},{"subitem_text_value":"海洋研究開発機構"},{"subitem_text_value":"国立医薬品食品研究所"},{"subitem_text_value":"徳島大学"},{"subitem_text_value":"静岡県立大学"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"Azabu University"},{"subitem_text_value":"Azabu University"},{"subitem_text_value":"Azabu University"},{"subitem_text_value":"Azabu University"},{"subitem_text_value":"The University of Tokyo"},{"subitem_text_value":"The University of Tokyo"},{"subitem_text_value":"RIKEN Genomic Sciences Center"},{"subitem_text_value":"Japan Agency for Marine-Earth Science and Technology"},{"subitem_text_value":"National Institute of Health Sciences"},{"subitem_text_value":"The University of Tokushima Graduate School"},{"subitem_text_value":"University of Shizuoka School of Pharmaceutical Science"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000259"},{"subitem_text_value":"000247"},{"subitem_text_value":"000075"},{"subitem_text_value":"000129"},{"subitem_text_value":"-"},{"subitem_text_value":"-"},{"subitem_text_value":"-"},{"subitem_text_value":"-"},{"subitem_text_value":"-"},{"subitem_text_value":"-"},{"subitem_text_value":"-"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"村上, 賢"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"森田, 英利"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"加藤, 行男"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"久松, 伸"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大島, 健志朗"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"服部, 正平"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤, 英博"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高見, 英人"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"五十君, 靜信"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"桑原, 知巳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高木, 邦明"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Masaru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morita, Hidetoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Yukio","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hisamatsu, 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第2報","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト腸内細菌のゲノム情報に基づく機能解析と生体影響 : 第2報"},{"subitem_title":"Functional analysis and in vivo effects on genomics of human intestinal flora : No. 2","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["245","264","280","281","450"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-02-21"},"publish_date":"2014-02-21","publish_status":"0","recid":"3613","relation_version_is_last":true,"title":["ヒト腸内細菌のゲノム情報に基づく機能解析と生体影響 : 第2報"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-12-19T06:00:14.137821+00:00"}