| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-10 |
| タイトル |
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タイトル |
Maternal approach behaviors toward neonatal calls are impaired by mother's experiences of raising pups with a risk gene variant for autism |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kato, Risa
Machida, Akihiro
Nomoto, Kensaku
Kang, Gina
Hiramoto, Takeshi
Tanigaki, Kenji
Mogi, Kazutaka
Hiroi, Noboru
Kikusui, Takefumi
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| Abstract |
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内容記述タイプ |
Abstract |
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内容記述 |
How the intrinsic sequence structure of neonatal mouse pup ultrasonic vocalization (USV) and maternal experiences determine maternal behaviors in mice is poorly understood. Our previous work showed that pups with a Tbx1 heterozygous (HT) mutation, a genetic risk for autism spectrum disorder (ASD), emit altered call sequences that do not induce maternal approach behaviors in C57BL6/J mothers. Here, we tested how maternal approach behaviors induced by wild-type and HT USVs are influenced by the mother's experience in raising pups of these two genotypes. The results showed that wild-type USVs were effective in inducing maternal approach behaviors when mothers raised wild-type but not HT pups. The USVs of HT pups were ineffective regardless of whether mothers raised HT or wild-type pups. However, the sequence structure of pup USVs had no effect on the general, non-directional incentive motivation of maternal behaviors. Our data show how the mother's experience with a pup with a genetic risk for ASD alters the intrinsic incentive values of USV sequences in maternal approach behaviors. |
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言語 |
en |
| 書誌情報 |
Developmental Psychobiology
巻 63,
号 1,
p. 108-113,
発行日 2021-01
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| 出版者 |
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出版者 |
Wiley |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1002/dev.22006 |
| 著者版フラグ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 査読 |
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内容記述タイプ |
Other |
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内容記述 |
査読あり |
Kato2020Pup.pdf (568 KB)
