| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-10 |
| タイトル |
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|
タイトル |
Cyclic Phthalate Esters as Liver X Receptor Antagonists with Anti-hepatitis C Virus and Anti-severe Acute Respiratory Syndrome Coronavirus 2 Properties |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Saito, Shiki
Ohashi, Hirofumi
Nakamura, Kou
Otagaki, Junichiro
Nishioka, Kazane
Nishiuchi, Kota
Nakamura, Ayaka
Tsurukawa, Yukine
Shibasaki, Hisanobu
Murakami, Hironobu
Nagane, Masaki
Okada, Maiko
Kuramochi, Kouji
Watashi, Koichi
Kamisuki, Shinji
|
| Abstract |
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内容記述タイプ |
Abstract |
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内容記述 |
The liver X receptor is a nuclear hormone receptor that regulates lipid metabolism. Previously, we had demonstrated the antiviral properties of a liver X receptor antagonist associated with the hepatitis C virus and severe acute respiratory syndrome coronavirus 2. In this study, we screened a chemical library and identified two potential liver X receptor antagonists. Spectroscopic analysis revealed that the structures of both antagonists (compounds 1 and 2) were cyclic dimer and trimer of esters, respectively, that consisted of phthalate and 1,6-hexane diol. This study is the first to report the structure of the cyclic trimer of phthalate ester. Further experiments revealed that the compounds were impurities of solvents used for purification, although their source could not be traced. Both phthalate esters exhibited anti-hepatitis C virus activity, whereas the cyclic dimer showed anti-severe acute respiratory syndrome coronavirus 2 activity. Cyclic phthalate derivatives may constitute a novel class of liver X receptor antagonists and broad-spectrum antivirals. |
|
言語 |
en |
| 書誌情報 |
Chemical and Pharmaceutical Bulletin
巻 70,
号 10,
p. 679-683,
発行日 2022-10-01
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| 出版者 |
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|
出版者 |
The Pharmaceutical Society of Japan |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1248/cpb.c22-00345 |
| 著者版フラグ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 査読 |
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|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
Saito_CPB.pdf (462 KB)
