| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-02-25 |
| タイトル |
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|
タイトル |
Isolation, structural determination, and antiviral activities of a novel alanine-conjugated polyketide from Talaromyces sp |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Mosu, Nozomi
Yasukochi, Mitsuki
Nakajima, Shogo
Nakamura, Kou
Ogata, Masaya
Iguchi, Keita
Kanno, Kazuki
Ishikawa, Tomohiro
Sugita, Kazutoshi
Murakami, Hironobu
Kuramochi, Kouji
Saito, Tatsuo
Takeda, Shiro
Watashi, Koichi
Fujino, Kan
Kamisuki, Shinji
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| Abstract |
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内容記述タイプ |
Abstract |
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内容記述 |
Antiviral agents are highly sought after. In this study, a novel alkylated decalin-type polyketide, alaspelunin, was isolated from the culture broth of the fungus Talaromyces speluncarum FMR 16671, and its structure was determined using spectroscopic analyses (1D/2D NMR and MS). The compound was condensed with alanine, and its absolute configuration was determined using Marfey's method. Furthermore, the antiviral activity of alaspelunin against various viruses was evaluated, and it was found to be effective against both severe acute respiratory syndrome coronavirus 2 and pseudorabies (Aujeszky's disease) virus, a pathogen affecting pigs. Our results suggest that this compound is a potential broad-spectrum antiviral agent. |
|
言語 |
en |
| 書誌情報 |
The Journal of Antibiotics
巻 77,
号 8,
p. 499-505,
発行日 2024-05-30
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| 出版者 |
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出版者 |
Springer Nature |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1038/s41429-024-00740-4 |
| 著者版フラグ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 査読 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
R2_Mosu_JA260213_merged.pdf (632 KB)
