| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-10 |
| タイトル |
|
|
タイトル |
Relationship of parathyroid hormone-related protein and neonatal mineral metabolism in dairy cow placentas |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kazama, Kei
Nishio, Takuma
Nagane, Masaki
Arai, Sachiko
Onda, Ken
|
| Abstract |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Parathyroid hormone-related protein (PTHrP) plays essential roles in placental calcium (Ca) transport, and it has been speculated that PTHrP in the placenta is regulated by calcium-sensing receptors (CaSR). This study clarified the relationship between PTHrP in the placenta of dairy cows and minerals in the fetal blood. Blood samples were obtained from 21 Holstein cows and 17 neonatal calves as well as 12 umbilical veins and arteries during cesarean section. After fetus removal, 13 caruncles and cotyledons were obtained. Concentrations of plasma PTHrP and serum minerals were measured. Real-time polymerase chain reaction (RT-qPCR) analyzed the gene expression of PTHrP and CaSR in the placenta. As a result, serum Ca and inorganic phosphorus concentrations in the neonate, umbilical vein, and artery were significantly higher than in the mother. Additionally, plasma PTHrP was detected in the bovine neonatal jugular vein, umbilical artery, and vein. PTHrP gene expression was significantly higher in the caruncles than in cotyledons; however, CaSR gene expression was higher in the cotyledons than in caruncles. These findings suggest that the PTHrP obtained from the placenta influences Ca homeostasis in the bovine fetus. |
|
言語 |
en |
| 書誌情報 |
Animal Science Journal
巻 93,
号 1,
p. e13723-e13723,
発行日 2022-04-26
|
| 出版者 |
|
|
出版者 |
Wiley |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1344-3941 |
| DOI |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1111/asj.13723 |
| 著者版フラグ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 査読 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
ASJ-2021-0609.R2_Proof_fl.pdf (577 KB)
