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Cutaneous anaphylactoid reaction to polyoxyethylene hydrogenated castor oil in dogs
https://az.repo.nii.ac.jp/records/2000530
https://az.repo.nii.ac.jp/records/2000530c57a5f77-4ee3-4897-b046-db6179aa7dd1
| 名前 / ファイル | ライセンス | アクション |
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PDF_Proof.PDF (3.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2026-02-25 | |||||||||||||||||
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| タイトル | Cutaneous anaphylactoid reaction to polyoxyethylene hydrogenated castor oil in dogs | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
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| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 著者 |
Sugiyama, Yukina
× Sugiyama, Yukina
× Kawarai, Shinpei
× Ansai, Shinichi
× Bist, Pradeep
× N.,Abraham, Soman
× Maruo, Takuya
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| Abstract | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Background Polyoxyethylene hydrogenated castor oil (HCO ethoxylates) is a nonionic surfactant used as an excipient for ointments and injections in human and veterinary drugs. Several polyethylene glycol (PEG) derivatives can be obtained depending on the number of moles of ethylene oxide (EO). HCO ethoxylates have the potential to cause anaphylactoid reactions. There is little published information about these types of reactions in dogs. Objective To determine the potential for HCO-ethoxylate-containing drugs to cause anaphylactoid reactions in dogs, employing intradermal testing (IDT) with various concentrations of HCO ethoxylates (HCO-25, -40, -60 and -80). Animals Four healthy male laboratory dogs. Materials and Methods We performed IDT with drugs containing HCO ethoxylates and HCO ethoxylates alone to determine threshold concentrations. The IDT scores and threshold concentrations were compared. Analysis of skin biopsies from IDT sites was used to measure the percentage of degranulated mast cells. The effect of histamine at IDT sites was investigated by pre-treatment with an antihistamine. Results All HCO-ethoxylate-containing drugs caused a wheal-and-flare reaction. The threshold concentrations (0.001% and 0.00001%) of each HCO-ethoxylate depended on the number of moles of EO (p < 0.05). Mast cell degranulation was enhanced by all HCO ethoxylates. The HCO-60-induced reaction was suppressed by an oral antihistamine. Conclusions and Clinical Relevance The threshold concentration can serve as a consideration for developing safe new drug formulations and for clinical decision-making around using drugs containing PEG derivatives. IDT is useful to predict the risk of adverse effects. Antihistamines could demonstrate a prophylactic effect. |
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| 言語 | en | |||||||||||||||||
| 書誌情報 |
Veterinary Dermatology 巻 35, 号 3, p. 263-272, 発行日 2024-12-18 |
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| 出版者 | Wiley | |||||||||||||||||
| DOI | ||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | 10.1111/vde.13228 | |||||||||||||||||
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| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | 査読あり | |||||||||||||||||
