| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-03-14 |
| タイトル |
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|
タイトル |
Whole blood transfusion in common marmosets: a clinical evaluation |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yurimoto, Terumi
Mineshige, Takayuki
Shinohara, Haruka
Inoue, Takashi
Sasaki, Erika
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| Abstract |
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内容記述タイプ |
Abstract |
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内容記述 |
In veterinary medicine, blood transfusion is commonly performed on companion animals. The common marmoset is a small nonhuman primate with increasing popularity as an animal model in biomedical research. Because of its small whole blood volume, the marmoset is at high risk of exsanguination, and blood transfusion is required to care for life-threatening bleeding. However, few clinical evaluations exist on transfusions for marmosets. This study performed whole blood transfusion with cross-matching on nine marmosets and surveyed the therapeutic effects. Recipients included clinical cases with persistent bleeding, anemia, and coma, as well as animals subjected to postoperative bleeding prophylaxis. Donors were selected from healthy marmosets, including littermates. Cross-match assay before transfusion were all negative, and recipients showed no visible signs of transfusion-related adverse reactions. Whole blood transfusions caused hemostasis and successful recovery in bleeding marmosets, including long-term improvement of anemia cases. Our results indicated that blood transfusion is effective for marmosets with severe anemia and persistent hemorrhage from both non-experimental and surgical causes. Furthermore, DNA sequencing for blood-group classification revealed that all subject marmosets were type A, suggesting that the risk of blood type mismatch may be low in this species. |
|
言語 |
en |
| bibliographic_information |
Experimental Animals
巻 71,
号 2,
p. 131-138,
発行日 2022
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| 出版者 |
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出版者 |
Japanese Association for Laboratory Animal Science |
| item_10002_relation_14 |
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識別子タイプ |
DOI |
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関連識別子 |
10.1538/expanim.21-0134 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| item_1730428627434 |
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|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
71_21-0134.pdf (1.3 MB)
