| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-03-14 |
| タイトル |
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|
タイトル |
Expression of P-glycoprotein and breast cancer resistance protein in three cases of canine lymphoma showing drug resistance |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Hyokai, Sachiko
Tanaka, Hiroyo
Aihara, Noriyuki
Kamiie, Junichi
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| Abstract |
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内容記述タイプ |
Abstract |
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内容記述 |
In canine lymphoma, drug resistance is the major factor hindering treatment. In this study, we performed immunohistochemical examination of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), which are considered as transporters related to multidrug resistance in three recurrent canine lymphomas. All cases were negative for both transporters before anticancer drug administration, but became positive after this administration. The expression was confirmed in capillary endothelial cells, such as in brain capillaries acting as the blood-brain barrier (BBB). It is suggested that both transporters expressed on capillary endothelial cells in lymphoma tissue may inhibit the spread of anticancer drugs into tumor tissues from blood, the same as the BBB. Therefore, capillary endothelial cells could act as a blood-tumor barrier, which might be involved in drug resistance in canine lymphoma. |
|
言語 |
en |
| bibliographic_information |
The Journal of Veterinary Medical Science
巻 83,
号 3,
p. 473-477,
発行日 2021-04-03
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| 出版者 |
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出版者 |
The Japanese Society of Veterinary Science |
| item_10002_relation_14 |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1292/jvms.20-0718 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| item_1730428627434 |
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内容記述タイプ |
Other |
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内容記述 |
査読あり |
Journal of Veterinary Medical Science.pdf (1.8 MB)
