| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-03-14 |
| タイトル |
|
|
タイトル |
Lipid-soluble polyphenols from sweet potato exert antitumor activity and enhance chemosensitivity in breast cancer |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kato, Kazuhiro
Nagane, Masaki
Aihara, Naoyuki
Kamiie, Junichi
Miyanabe, Masakatsu
Hiraki, Shinobu
Luo, Xiaolin
Nakanishi, Ikuo
Shoji, Yoshimi
Matsumoto, Ken-Ichiro
Yamashita, Tadashi
|
| Abstract |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Polyphenols are abundant in vegetables and fruit. They have been shown to have various antitumor, antioxidant, and anti-inflammatory effects. Here, we extracted the lipid-soluble fraction of polyphenols from fermented sweet potato (Ipomoea batatas). These lipid-soluble polyphenols mainly contained caffeic acid derivatives with strong antioxidant ability, which we hypothesized to affect diseases for which oxidative stress is a factor, such as cancer. We therefore investigated the antitumor and chemo-sensitizing effects of lipid-soluble polyphenols on E0771 murine breast cancer cells. The lipid-soluble polyphenols accumulated in the cells’ cytoplasm due to its high lipophilicity, and reduced reactive oxygen species through its strong antioxidant activity. The lipid-soluble polyphenols also arrested the cell cycle at G0/G1 by suppressing Akt activity, and enhanced the cytotoxicity of anticancer agents. In this model, lipid-soluble polyphenols inhibited tumor growth and enhanced the efficacy of chemotherapy drugs. These results suggest the potential of lipid-soluble polyphenols as a functional food to support cancer therapy. |
|
言語 |
en |
| bibliographic_information |
Journal of clinical biochemistry and nutrition
巻 68,
号 3,
p. 193-200,
発行日 2021-05-01
|
| 出版者 |
|
|
出版者 |
Society for Free Radical Research Japan |
| item_10002_relation_14 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.3164/jcbn.20-73 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| item_1730428627434 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
68_20-73.pdf (960 KB)
