| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-03-14 |
| タイトル |
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タイトル |
Serum concentration and safety of intravenous drip versus subcutaneous administration of carboplatin in dogs |
|
言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Iwano, Masataka
Sadahiro, Kohei
Maruo, Takuya
Kawarai, Shinpei
Kayanuma, Hideki
Orito, Kensuke
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| Abstract |
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内容記述タイプ |
Abstract |
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内容記述 |
Carboplatin is used to treat certain cancers in dogs and cats and is routinely administered via intravenous drip (IVD). Subcutaneous (SC) administration has also been described. However, the toxicity, serum concentrations, and area under blood concentration-time curves (AUCs) of SC carboplatin are unknown. This study aimed to compare serum carboplatin concentrations in dogs after SC and IVD and to monitor any adverse events. In this crossover study, five dogs received SC or IV carboplatin (300 mg/m2). After a minimum of 3 weeks, each dog received the other treatment. No gross skin toxicity or abnormal clinical signs were observed in any of the dogs. Blood test abnormalities were detected in most dogs. Decreased neutrophil and platelet counts, and increased C-reactive protein (CRP) levels were found. There was no significant difference in the neutropenia, thrombocytopenia, and CRP scores between the groups. Systemic toxicities of SC carboplatin were comparable to those of IVD carboplatin. The time to maximum carboplatin concentration after SC was longer than that after IVD (P<0.001). SC carboplatin remained in the serum longer than IVD carboplatin (P=0.008). The AUC of SC was less than that of IVD (P=0.002). The AUC and time taken to reach the maximum concentration of SC carboplatin were lower than those of IVD carboplatin. This study suggests that SC carboplatin may be an efficacious option for the treatment of tumors in dogs, particularly where IVD administration is challenging. |
|
言語 |
en |
| bibliographic_information |
The Journal of Veterinary Medical Science
巻 83,
号 5,
p. 775-779,
発行日 2021-05-09
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| 出版者 |
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出版者 |
The Japanese Society of Veterinary Science |
| item_10002_relation_14 |
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識別子タイプ |
DOI |
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関連識別子 |
10.1292/jvms.20-0653 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| item_1730428627434 |
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内容記述タイプ |
Other |
|
内容記述 |
査読あり |
83_20-0653.pdf (822 KB)
