| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-03-14 |
| タイトル |
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タイトル |
Isolation, structural determination, and antiviral activities of metabolites from vanitaracin A-producing Talaromyces sp |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kamisuki, Shinji
Shibasaki, Hisanobu
Murakami, Hironobu
Fujino, Kan
Tsukuda, Senko
Kojima, Ikumi
Ashikawa, Koudai
Kanno, Kazuki
Ishikawa, Tomohiro
Saito, Tatsuo
Sugawara, Fumio
Watashi, Koichi
Kuramochi, Kouji
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| 抄録 |
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内容記述タイプ |
Abstract |
| Abstract |
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内容記述タイプ |
Abstract |
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内容記述 |
Vanitaracin A, an anti-hepatitis B virus polyketide, has been previously isolated from Talaromyces sp. In the present study, we searched for novel compounds in the culture broth obtained from a vanitaracin A-producing fungus under various conditions. Three novel compounds (vanitaracin C, vanitaraphilone A, and 2-hydroxy-4(hydroxymethyl)-6-methylbenzaldehyde) were isolated, and their structures were determined using spectroscopic methods (1D/2D NMR and MS). In addition, the antiviral spectrum of vanitaracin A was examined by measuring its antiviral activities against rabies virus, Borna disease virus 1, and bovine leukemia virus. This compound exhibited antiviral activity against bovine leukemia virus, which is the causative agent of enzootic bovine leukosis. The anti-bovine leukemia virus effects of other compounds isolated from the vanitaracin A-producing fungus, namely, vanitaracins B and C, vanitaraphilone A, and 2-hydroxy-4-(hydroxymethyl)-6-methylbenzaldehyde, were also evaluated. Vanitaracin B, vanitaraphilone A and 2-hydroxy-4-(hydroxymethyl)-6methylbenzaldehyde were also found to exhibit activity against bovine leukemia virus. These findings reveal the broad-spectrum antiviral activity of the vanitaracin scaffold and suggest several candidates for the development of anti-bovine leukemia virus drugs. |
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言語 |
en |
| bibliographic_information |
The Journal of antibiotics
巻 76,
号 2,
p. 75-82,
発行日 2023-02
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| 出版者 |
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出版者 |
Springer Nature |
| item_10002_relation_14 |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/s41429-022-00585-9 |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| item_1730428627434 |
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内容記述タイプ |
Other |
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内容記述 |
査読あり |
Kamisuki JA2023.pdf (411 KB)
