| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-02-28 |
| タイトル |
|
|
タイトル |
Roles of zinc signaling in mammalian reproduction |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kageyama, Atsuko
Terakawa, Jumpei
Ito, Junya
Kashiwazaki, Naomi
|
| Abstract |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Zinc is a critical trace element that is important for cellular function in both female and male reproductive organs.Zinc imbalance and/or altered zinc signaling causes multiple disorders in the reproductive process, including oogenesis, spermatogenesis, fertilization, and embryogenesis. Extracellular and intracellular dynamics of zinc ions are regulated by cell-specific transporters, i.e., Zrt-, Irt-related protein (ZIP) or zinc transporter (ZnT), which respectively transport zinc ions in or out of the cytoplasm through biological membranes. The expression and function of these transporters vary among cell types. The elucidation of the mechanisms underlying zinc homeostasis and zinc dynamics in reproductive function will lead to better infertility treatments for humans as well as the improvement of livestock production. In this review, we discuss the essential roles of zinc signaling in the key events in mammalian reproduction, with a focus on the period from gametogenesis to embryonic development. |
|
言語 |
en |
| bibliographic_information |
Metallomics Research
巻 2,
号 1,
p. 64-73,
発行日 2022-06-16
|
| 出版者 |
|
|
出版者 |
Japan Society for Biomedical Research on Trace Elements |
| item_10002_relation_14 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.11299/metallomicsresearch.MR202112 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| item_1730428627434 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
22-1-MR202112.pdf (1.3 MB)
