| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-02-28 |
| タイトル |
|
|
タイトル |
Regulation of Hypoxic Signaling and Oxidative Stress via the MicroRNA–SIRT2 Axis and Its Relationship with Aging-Related Diseases |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kaitsuka, Taku
Matsushita, Masayuki
Matsushita, Nobuko
|
| Abstract |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The sirtuin family of nicotinamide adenine dinucleotide-dependent deacetylase and ADP-ribosyl transferases plays key roles in aging, metabolism, stress response, and aging-related diseases. SIRT2 is a unique sirtuin that is expressed in the cytosol and is abundant in neuronal cells. Various microRNAs were recently reported to regulate SIRT2 expression via its 3′-untranslated region (UTR), and single nucleotide polymorphisms in the miRNA-binding sites of SIRT2 3′-UTR were identified in patients with neurodegenerative diseases. The present review highlights recent studies into SIRT2-mediated regulation of the stress response, posttranscriptional regulation of SIRT2 by microRNAs, and the implications of the SIRT2–miRNA axis in aging-related diseases. |
|
言語 |
en |
| bibliographic_information |
Cells
巻 10,
号 12,
p. 3316-3316,
発行日 2021-11-26
|
| 出版者 |
|
|
出版者 |
MDPI AG |
| item_10002_relation_14 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.3390/cells10123316 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| item_1730428627434 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
cells-10-03316-v2.pdf (838 KB)
