{"created":"2025-02-14T06:14:37.514807+00:00","id":2000337,"links":{},"metadata":{"_buckets":{"deposit":"48f59908-a4aa-4684-bd2e-66e985ad25a2"},"_deposit":{"created_by":55,"id":"2000337","owners":[55],"pid":{"revision_id":0,"type":"depid","value":"2000337"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:02000337","sets":["423"]},"author_link":["17460","23709","23789","23790","23710","23711","1580","23719","23714","23791","23792","23715","23716","1673"],"control_number":"2000337","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-01-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"36","bibliographicPageStart":"32","bibliographicVolumeNumber":"71","bibliographic_titles":[{"bibliographic_title":"医学検査"},{"bibliographic_title":"The Japanese journal of medical technology"}]}]},"item_10002_description_25":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Objective: Mu-opioid receptor gene OPRM1 118A>G polymorphisms have been considered possible candidate factors for both opioid effects and psychophysical responses. In this study, we investigate the association between OPRM1 118A>G polymorphisms and personality traits. Method: After written informed consent was obtained from participants, OPRM1 118A>G gene polymorphisms were analyzed by polymerase chain reaction (PCR)—restriction fragment length polymorphism (RFLP), and personality was assessed using Neuroticism Extraversion Openness-Five Factor Inventory (NEO-FFI) and State-Trait Anxiety Inventory (STAI) in 236 Japanese university students. Statistical analyses were performed by the unpaired t-test and Welch’s t-test. Results: A significant relationship was found between OPRM1 118A>G polymorphisms and NEO-FFI and STAI scores: participants with the A allele exhibited a higher conscientiousness score (p = 0.024) and a lower neuroticism score (p = 0.065) in NEO-FFI, and a lower STAI score (p = 0.023) than those without the A allele. Conclusion: We conclude that OPRM1 may affect conscientiousness and neuroticism measured using NEO-FFI and trait anxiety measured using STAI.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"モルヒネの標的分子であるμオピオイド受容体（以下，OPRM1）に注目し，OPRM1遺伝子多型でその発現レベルや機能的活性に影響をもたらす118A/G（rs1799971）と人格特性との関連性があるかどうか検討を行った。若年者236人（男性55人，女性181人）を対象とし，対象者からインフォームドコンセントを得た後採血し，DNAの抽出・精製を行った。OPRM1遺伝子多型の解析には，polymorphism chain reaction-restriction fragment length polymorphism（PCR-RFLP）法を用いた。また，人格特性との関連性を調べるために，全ての対象者に自己記入式人格検査であるNEO Five Factor Inventory（NEO-FFI）とstate-trait anxiety inventory（STAI状態－特性不安検査）を実施した。その結果，Aアレル非保有者に比べ，Aアレル保有者ではNEO-FFIの誠実性スコアが有意差に高く（p = 0.024），Aアレル非保有者ではSTAI特性不安スコアが有意に高いことが分かった（p = 0.023）。今回の結果より，OPRM1遺伝子多型118A/Gが人格特性の「誠実性」および「特性不安」に影響を与えているのではないかと考えられた。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10002_publisher_26":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本臨床衛生検査技師会"},{"subitem_publisher":"Japanese Association of Medical Technologists"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.14932/jamt.21-75","subitem_relation_type_select":"DOI"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-8669","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1730428627434":{"attribute_name":"査読","attribute_value_mlt":[{"subitem_description":"査読あり","subitem_description_type":"Other"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小野澤, 裕也","creatorNameLang":"ja"}],"familyNames":[{"familyName":"小野澤","familyNameLang":"ja"}],"givenNames":[{"givenName":"裕也","givenNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"17460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"金剛, 左京","creatorNameLang":"ja"}],"familyNames":[{"familyName":"金剛","familyNameLang":"ja"}],"givenNames":[{"givenName":"左京","givenNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"23709","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野, 優","creatorNameLang":"ja"}],"familyNames":[{"familyName":"高野","familyNameLang":"ja"}],"givenNames":[{"givenName":"優","givenNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"23789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川, 菜生","creatorNameLang":"ja"}],"familyNames":[{"familyName":"古川","familyNameLang":"ja"}],"givenNames":[{"givenName":"菜生","givenNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"23790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三上, 麻里奈","creatorNameLang":"ja"}],"familyNames":[{"familyName":"三上","familyNameLang":"ja"}],"givenNames":[{"givenName":"麻里奈","givenNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"23710","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木, 理詠","creatorNameLang":"ja"}],"familyNames":[{"familyName":"青木","familyNameLang":"ja"}],"givenNames":[{"givenName":"理詠","givenNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"23711","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩橋, 和彦","creatorNameLang":"ja"}],"familyNames":[{"familyName":"岩橋","familyNameLang":"ja"}],"givenNames":[{"givenName":"和彦","givenNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1580","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Onozawa, Yuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Onozawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Yuya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23719","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kongo, Sakyo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kongo","familyNameLang":"en"}],"givenNames":[{"givenName":"Sakyo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23714","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takano, Yu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takano","familyNameLang":"en"}],"givenNames":[{"givenName":"Yu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, Nao","creatorNameLang":"en"}],"familyNames":[{"familyName":"Furukawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Nao","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mikami, Marina","creatorNameLang":"en"}],"familyNames":[{"familyName":"Mikami","familyNameLang":"en"}],"givenNames":[{"givenName":"Marina","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23715","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Rie","creatorNameLang":"en"}],"familyNames":[{"familyName":"Aoki","familyNameLang":"en"}],"givenNames":[{"givenName":"Rie","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23716","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwahashi, Kazuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Iwahashi","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1673","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-02-14"}],"filename":"ja.pdf","filesize":[{"value":"574 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population","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"55","path":["423"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-02-28"},"publish_date":"2025-02-28","publish_status":"0","recid":"2000337","relation_version_is_last":true,"title":["PCR法を用いたμオピオイド受容体(OPRM1)118A/G遺伝子多型と人格特性との関連についての研究"],"weko_creator_id":"55","weko_shared_id":4},"updated":"2025-02-14T06:38:41.273415+00:00"}