| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-02-28 |
| タイトル |
|
|
タイトル |
Sphingomyelin maintains the cutaneous barrier via regulation of the STAT3 pathway |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Komuro, Mariko
Nagane, Masaki
Fukuyama, Tomoki
Luo, Xiaolin
Hiraki, Shinobu
Miyanabe, Masakatsu
Ishikawa, Miyuki
Niwa, Chiaki
Murakami, Hironobu
Okamoto, Mariko
Yamashita, Tadashi
|
| Abstract |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Epidermal tissues play vital roles in maintaining homeostasis and preventing the dysregulation of the cutaneous barrier. Sphingomyelin (SM), a sphingolipid synthesized by sphingomyelin synthase (SMS) 1 and 2, is involved in signal transduction via modulation of lipid-raft functions. Though the implications of SMS on inflammatory diseases have been reported, its role in dermatitis has not been clarified. In this study, we investigated the role of SM in the cutaneous barrier using a dermatitis model established by employing Sgms1 and 2 deficient mice. SM deficiency impaired the cutaneous inflammation and upregulated signal transducer and activator of transcription 3 (STAT3) phosphorylation in epithelial tissues. Furthermore, using mouse embryonic fibroblast cells, the sensitivity of STAT3 to Interleukin-6 stimulation was increased in Sgms-deficient cells. Using tofacitinib, a clinical JAK inhibitor, the study showed that SM deficiency might participate in STAT3 phosphorylation via JAK activation. Overall, these results demonstrate that SM is essential for maintaining the cutaneous barrier via the STAT3 pathway, suggesting SM could be a potential therapeutic target for dermatitis treatment. |
|
言語 |
en |
| 書誌情報 |
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
巻 36,
号 4,
p. e22111,
発行日 2022-04
|
| 出版者 |
|
|
出版者 |
Wiley |
| DOI |
|
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1096/fj.202100721RR |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 査読 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
The FASEB Journal - 2022 - Komuro - Sphingomyelin maintains the cutaneous barrier via regulation of the STAT3 pathway.pdf (1.6 MB)
