| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-02-14 |
| タイトル |
|
|
タイトル |
First Isolation and Identification of Homologous Recombination Events of Porcine Adenovirus from Wild Boar |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Oba, Mami
Borjigin, Sumiya
Kikuchi, Fuka
Oi, Toru
Takemae, Hitoshi
Ishida, Hiroho
Murakami, Hironobu
Aihara, Naoyuki
Shiga, Takanori
Kamiie, Junichi
Mizutani, Tetsuya
Nagai, Makoto
|
| Abstract |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Porcine adenoviruses (PAdVs) are distributed in pig populations and classified into five immunologically distinct serotypes (PAdV-1 to 5). In this study, a PAdV was isolated from a fecal sample of wild boar for the first time. Whole-genome analysis revealed that this strain (Ino5) has sequence homology (approximately > 93%) throughout the genome with the PAdV-5 strain HNF-70 that was isolated from a pig in Japan in 1987, except for the hexon, E3 612R, and fiber coding regions. Two possible recombination breakpoints were detected in the hexon and E3 612R regions, which were found to have reduced GC content. Structural prediction analysis showed that a part of the hexon protein corresponding to the tower region of Ino5 had structural differences when compared with HNF-70, suggesting antigenic heterogeneity between these strains. PAdVs were detected in 1.77% (2/113) and 12% (12/100) of the fecal samples from wild boars and pigs collected in Japan by PCR, respectively. Phylogenetic analyses of the hexon and fiber genes revealed that some samples showed different grouping in the hexon and fiber genes, suggesting that these viruses have recombination events. These findings suggest that the PAdV-5 has evolved with homologous recombination events in the same manner as human adenoviruses among not only pig populations, but also wild boars in Japan. |
|
言語 |
en |
| 書誌情報 |
Viruses
巻 14,
号 11,
p. 2400-2400,
発行日 2022-10-29
|
| 出版者 |
|
|
出版者 |
MDPI AG |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.3390/v14112400 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 査読 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
viruses-14-02400-v3.pdf (2.1 MB)
