| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-02-03 |
| タイトル |
|
|
タイトル |
The novel sustained 3-hydroxybutyrate donor poly-D-3-hydroxybutyric acid prevents inflammatory bowel disease through upregulation of regulatory T-cells |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Suzuki, Rimina
Mishima, Mayuko
Nagane, Masaki
Mizugaki, Hinano
Suzuki, Takehito
Komuro, Mariko
Shimizu, Takuto
Fukuyama, Tomoki
Takeda, Shiro
Ogata, Masaya
Miyamoto, Takayoshi
Aihara, Naoyuki
Kamiie, Junichi
Kamisuki, Shinji
Yokaryo, Hiroto
Yamashita, Tadashi
Satoh, Takumi
|
| Abstract |
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内容記述タイプ |
Abstract |
|
内容記述 |
The matrilineal transmission of maternal behavior has been reported in several species. Studies, primarily on rats, have suggested the importance of postnatal experience and the involvement of epigenetic mechanisms in mediating these transmissions. This study aims to determine whether the matrilineal transmission of maternal behavior occurs in mice and whether the microbiota is involved. We first observed that early weaned (EW) female mice showed lower levels of maternal behavior, particularly licking/grooming (LG) of their own pups, than normally weaned (NW) female mice. This difference in maternal behavioral traits was also observed in the second generation, even though all mice were weaned normally. In the subsequent cross-fostering experiment, the levels of LG were influenced by the nurturing mother but not the biological mother. Finally, we transplanted the fecal microbiota from EW or NW mice into germ-free (GF) mice raising pups. The maternal behaviors that the pups exhibited toward their own offspring after growth were analyzed, and the levels of LG in GF mice colonized with microbiota from EW mice were lower than those in GF mice colonized with microbiota from NW mice. These results clearly indicate that, among maternal behavioral traits, LG is intergenerationally transmitted in mice and suggest that the vertical transmission of microbiota is involved in this process. This study demonstrates the universality of the intergenerational transmission of maternal behavioral traits and provides new insights into the role of microbiota. |
|
言語 |
en |
| 書誌情報 |
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
巻 37,
号 1,
p. e22708,
発行日 2022-12-23
|
| 出版者 |
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|
出版者 |
Wiley |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1096/fj.202200919R |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 査読 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
The FASEB Journal - 2022 - Suzuki - The novel sustained 3‐hydroxybutyrate donor poly‐D‐3‐hydroxybutyric acid prevents.pdf (32.5 MB)
