| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-01-24 |
| タイトル |
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|
タイトル |
Dasatinib attenuates airway inflammation of asthma exacerbation in mice induced by house dust mites and dsRNA |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Nishimoto, Yuki
Ando, Daiki
Irie, Kosuke
Kainuma, Ikumi
Katayama, Yuki
Sato, Shiori
Suzuki, Tomohiro
Harada, Mai
Yoshida, Tsubasa
Ito, Kazuhiro
Kizawa, Yasuo
|
| Abstract |
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内容記述タイプ |
Abstract |
|
内容記述 |
Asthma exacerbation is a significant clinical problem that causes resistance to corticosteroid therapy and elevated hospitalization risk. Src family kinases (SFKs) contribute to various steps of the immune response, such as airway inflammation in viral or bacterial infections and allergic asthma. Therefore, we determined the effects of dasatinib (DAS), a typical Src inhibitor, on a murine asthma exacerbation model induced by house dust mites (HDM) and synthetic analog of double-stranded RNA, poly(I:C). A/J mice were sensitized to intrapreneurial HDM twice every seven days and challenged with intranasal HDM once every second day for a total of six exposures, and/or exposed to poly(I:C) twice daily for three consecutive days. Drug treatments were performed twice daily for three days, starting one day after the last HDM challenge or 2 h before each poly(I:C) exposure. DAS improved poly(I:C)-induced acute inflammation dose-dependently. Both DAS and fluticasone propionate (FP) attenuated HDM-induced allergic airway inflammation. However, in HDM and poly(I:C) induced-asthma exacerbated mice, DAS significantly improved inflammatory cells in bronchoalveolar lavage fluid and histological changes in the lungs, whereas FP did not. Therefore, SFKs are important targets for controlling severe asthma refractory to conventional therapies. |
|
言語 |
en |
| 書誌情報 |
Biochemistry and Biophysics Reports
巻 33,
p. 101402,
発行日 2023-03
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| 出版者 |
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出版者 |
Elsevier BV |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.bbrep.2022.101402 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 査読 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
1-s2.0-S2405580822002023-main.pdf (4.2 MB)
