| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-01-15 |
| タイトル |
|
|
タイトル |
Fuzapladib reduces postsurgical inflammation in the intestinal muscularis externa |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kaji, Noriyuki
Iwaoka, Kosuzu
Nakamura, Shinichiro
Tsukamoto, Atsushi
|
| Abstract |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Postoperative ileus (POI) is a surgical complication that induces emesis and anorexia. Fuzapladib (FUZ), an inhibitor of leukocyte-function-associated antigen type 1 (LFA-1) activation, a leukocyte adhesion molecule, exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site. In this study, we examined the prophylactic impact of FUZ on POI in a mouse model. POI model mice were generated by intestinal manipulation, and the effect of FUZ on intestinal transit and the infiltration of inflammatory cells into the ileal muscularis externa was assessed. The increased number of macrophages was significantly suppressed by FUZ, whereas the infiltration of neutrophils into the ileal muscularis externa was not sufficiently inhibited in the POI model mice. Additionally, FUZ did not ameliorate delayed gastrointestinal transit in POI model mice. In conclusion, our results suggest that FUZ does not improve delayed gastrointestinal transit but partially inhibits inflammation in the ileal muscularis externa in POI model mice. FUZ may be a potential anti-inflammatory agent for the management of post-surgical inflammation. |
|
言語 |
en |
| 書誌情報 |
The Journal of veterinary medical science
巻 85,
号 11,
p. 1151-1156,
発行日 2023-11
|
| 出版者 |
|
|
出版者 |
The Japanese Society of Veterinary Science |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1292/jvms.23-0257 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 査読 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
85_23-0257.pdf (1.7 MB)
