| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-01-15 |
| タイトル |
|
|
タイトル |
G-protein-coupled estrogen receptor prevents nuclear factor-kappa B promoter activation by Helicobacter pylori cytotoxin-associated gene A in gastric cancer cells |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Okamoto, Mariko
Miura, Atsushi
Ito, Ryota
Kamada, Toshiki
Mizukami, Yoichi
Kawamoto, Keiko
|
| Abstract |
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内容記述タイプ |
Abstract |
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内容記述 |
Helicobacter pylori is a well-known pathogen that causes chronic gastritis, leading to the development of gastric cancer. This bacterium has also been detected in dogs, and symptoms similar to those in humans have been reported. The cytotoxin-associated gene A (CagA) is involved in pathogenesis through aberrant activation of host signal transduction, including the nuclear factor-kappa B (NF-κB) pathway. We have previously shown the anti-inflammatory effect of the G-protein-coupled estrogen receptor (GPER) via inhibiting of NF-κB activation in several cells. Therefore, here, we investigated the effect of GPER on CagA-mediated NF-κB promoter activity and showed that CagA overexpression in gastric cancer cells activated the NF-κB reporter and induced interleukin 8 (il-8) expression, both of which were inhibited by the GPER agonist. |
|
言語 |
en |
| 書誌情報 |
The Journal of veterinary medical science
巻 85,
号 12,
p. 1348-1354,
発行日 2023-11-13
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| 出版者 |
|
|
出版者 |
The Japanese Society of Veterinary Science |
| DOI |
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|
識別子タイプ |
DOI |
|
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関連識別子 |
10.1292/jvms.23-0054 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 査読 |
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|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
85_23-0054.pdf (1.7 MB)
