| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-12-24 |
| タイトル |
|
|
タイトル |
Coordination of prophage and global regulator leads to high enterotoxin production in staphylococcal food poisoning-associated lineage |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Sato'o, Yusuke
Hisatsune, Junzo
Aziz, Fatkhanuddin
Tatsukawa, Nobuyuki
Shibata-Nakagawa, Mari
Ono,K, Hisaya
Naito, Ikunori
Omoe, Katsuhiko
Sugai, Motoyuki
|
| Abstract |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Staphylococcus species in food produce Staphylococcal enterotoxins (SEs) that cause Staphylococcal food poisoning (SFP). More than 20 SE types have been reported, among which Staphylococcal enterotoxin A (SEA) has been recognized as one of the most important SEs associated with SFP. However, the regulatory mechanisms underlying its production remain unclear. Previously, we identified a major SFP clone in Japan, CC81 subtype-1, which exhibits high SEA production. In this study, we attempted to identify the factors contributing to this phenomenon. Thus, we demonstrated that the attenuation of the activity of endogenous regulator, Staphylococcal accessory regulator S (SarS), and the lysogenization of a high SEA-producing phage contributed to this phenomenon in CC81 subtype-1. Furthermore, our results indicated that SarS could directly bind to the promoter upstream of the sea gene and suppress SEA expression; this low SarS repression activity was identified as one of the reasons for the high SEA production observed. Therefore, we revealed that both exogenous and endogenous factors may probably contribute to the high SEA production. Our results confirmed that SE production is a fundamental and critical factor in SFP and clarified the associated production mechanism while enhancing our understanding as to why a specific clone frequently causes SFP. |
|
言語 |
en |
| 書誌情報 |
Microbiology Spectrum
巻 12,
号 3,
p. e0292723,
発行日 2024-02-06
|
| 出版者 |
|
|
出版者 |
American Society for Microbiology |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1128/spectrum.02927-23 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 査読 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
zhang-et-al-2024-coordination-of-prophage-and-global-regulator-leads-to-high-enterotoxin-production-in-staphylococcal.pdf (1.4 MB)
