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Comparative study of the effects of antitussive drugs in a canine acute cough model
https://az.repo.nii.ac.jp/records/2000203
https://az.repo.nii.ac.jp/records/2000203eada1d86-32be-41e9-b6cf-8e03bf6dc7e3
| 名前 / ファイル | ライセンス | アクション |
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Veterinary Medicine Sci - 2024 - Aoki - Comparative study of the effects of antitussive drugs in a canine acute cough.pdf (432 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2024-12-13 | |||||||||
| タイトル | ||||||||||
| タイトル | Comparative study of the effects of antitussive drugs in a canine acute cough model | |||||||||
| 言語 | en | |||||||||
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| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Aoki, Takuma
× Aoki, Takuma
× Eki, Kent
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| Abstract | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Background Cough is a common clinical complaint in small animal practice with limited treatment options for chronic underlying conditions. Objectives The present study aimed to evaluate the efficacy of three antitussive drugs in a novel, minimally invasive canine acute cough model. Methods Five clinically healthy Beagles were used to create an acute cough model by administering sterile saline via a transtracheally placed central venous catheter. Single-dose antitussive effects of butorphanol, maropitant and Danpron were assessed. Cough frequency was measured before and at hourly intervals up to 3 h post-administration of each drug, with a linear mixed model used for statistical analysis. Results Butorphanol (0.3 m/kg, IM) significantly reduced cough frequency at 1 and 3 h post-administration. Danpron (0.1 mL/kg, IM) also significantly reduced cough frequency 1 h post-administration; however, this effect was not sustained at 3 h. Maropitant (1 mg/kg, IM) did not significantly reduce cough frequency. The cough induction method was effective and minimally invasive, with no adverse effects. Conclusion The present study demonstrated that butorphanol has a potent and prolonged antitussive effect in an acute canine cough model, whereas Danpron shows a transient effect. These findings provide valuable insights into the comparative efficacy of commonly used antitussive drugs in dogs. |
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| 言語 | en | |||||||||
| 書誌情報 |
Veterinary Medicine and Science 巻 10, 号 5, p. 1-7, 発行日 2024-07-23 |
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| 出版者 | Wiley | |||||||||
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| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 2053-1095 | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1002/vms3.1549 | |||||||||
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| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 査読 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 査読あり | |||||||||
