| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-12-13 |
| タイトル |
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|
タイトル |
Modulation of gut microbiota composition due to early weaning stress induces depressive behavior during the juvenile period in mice |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kamimura, Itsuka
Miyauchi, Eiji
Takeuchi, Tadashi
Tsuchiya, Noriaki
Tamura, Kanami
Uesugi, Ayumi
Negishi, Hiroki
Taida, Takashi
Kato, Tamotsu
Kawasumi, Masami
Nagasawa, Miho
Mogi, Kazutaka
Ohno, Hiroshi
Kikusui, Takefumi
|
| Abstract |
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内容記述タイプ |
Abstract |
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内容記述 |
Background The gut microbiota plays an important role in the development of behavior and immunity in infants and juveniles. Early weaning (EW), a form of social stress in mice, leads to increased anxiety and an enhanced stress response in the hypothalamic-pituitary-adrenal axis during adulthood. Early life stress also modulates the immune system and increases vulnerability to infection. However, studies investigating the causal relationships among juvenile stress, microbiota changes, and immune and behavioral deficits are limited. Therefore, we hypothesized that EW alters gut microbiota composition and impairs the development of the nervous and immune systems.
Results EW mice moved longer distances in the marble-burying test and had longer immobility times in the tail suspension test than normal weaning (NW) mice. In parallel, the gut microbiome composition differed between NW and EW mice, and the abundance of Erysipelotrichacea in EW mice at 8 weeks of age was lower than that in NW mice. In an empirical study, germ-free mice colonized with the gut microbiota of EW mice (GF-EW mice) demonstrated higher depressive behavior than GF mice colonized with normal weaning microbiota (GF-NW mice). Immune cell profiles were also affected by the EW microbiota colonization; the number of CD4 + T cells in the spleen was reduced in GF-EW mice.
Conclusion Our results suggest that EW-induced alterations in the gut microbiota cause depressive behaviors and modulate the immune system. |
|
言語 |
en |
| 書誌情報 |
Animal Microbiome
巻 6,
号 1,
p. 1-12,
発行日 2024-06-20
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| 出版者 |
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出版者 |
Springer Nature |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1186/s42523-024-00322-7 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 査読 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
s42523-024-00322-7.pdf (4.6 MB)
