| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-12-13 |
| タイトル |
|
|
タイトル |
Eicosapentaenoic acid increases proportion of type 1 muscle fibers through PPARδ and AMPK pathways in rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Komiya, Yusuke
Sakazaki, Yuka
Goto, Tsuyoshi
Kawabata, Fuminori
Suzuki, Takahiro
Sato, Yusuke
Sawano, Shoko
Nakamura, Mako
Tatsumi, Ryuichi
Ikeuchi, Yoshihide
Arihara, Keizo
Mizunoya, Wataru
|
| Abstract |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Muscle fiber type composition (% slow-twitch and % fast-twitch fibers) is associated with metabolism, with increased slow-twitch fibers alleviating metabolic disorders. Previously, we reported that dietary fish oil intake induced a muscle fiber-type transition in a slower direction in rats. The aim of this study was to determine the functionality of eicosapentaenoic acid (EPA), a unique fatty acid in fish oil, to skeletal muscle fiber type and metabolism in rats. Here, we showed that dietary EPA promotes whole-body oxidative metabolism and improves muscle function by increasing proportion of slow-twitch type 1 fibers in rats. Transcriptomic and metabolomic analyses revealed that EPA supplementation activated the peroxisome proliferator-activated receptor δ (PPARδ) and AMP-activated protein kinase (AMPK) pathways in L6 myotube cultures, which potentially increasing slow-twitch fiber share. This highlights the role of EPA as an exercise-mimetic dietary component that improves metabolism and muscle function, with potential benefits for health and athletic performance. |
|
言語 |
en |
| 書誌情報 |
iScience
巻 27,
号 6,
p. 109816-109816,
発行日 2024-06-21
|
| 出版者 |
|
|
出版者 |
Elsevier BV |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2589-0042 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.isci.2024.109816 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| Other |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
PIIS2589004224010381.pdf (5.4 MB)
