| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-12-13 |
| タイトル |
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|
タイトル |
Molecular Mechanism of Oocyte Activation in Mammals: Past, Present, and Future Directions |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Sugita, Hibiki
Takarabe, Shunsuke
Kageyama, Atsuko
Kawata, Yui
Ito, Junya
|
| Abstract |
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内容記述タイプ |
Abstract |
|
内容記述 |
During mammalian fertilization, repetitive intracellular Ca2+ increases known as Ca2+ oscillations occur. These oscillations are considered crucial for successful fertilization and subsequent embryonic development. Numerous researchers have endeavored to elucidate the factors responsible for inducing Ca2+ oscillations across various mammalian species. Notably, sperm-specific phospholipase C zeta (PLCζ) emerged as a prominent candidate capable of initiating Ca2+ oscillations, particularly in mammals. Genetic mutation of PLCζ in humans results in the absence of Ca2+ oscillations in mouse oocytes. Recent studies further underscored PLCζ’s significance, revealing that sperm from PLCζ-deficient (Plcz1−/−) mice fail to induce Ca2+ oscillations upon intracytoplasmic sperm injection (ICSI). Despite these findings, observations from in vitro fertilization (IVF) experiments using Plcz1−/− sperm revealed some residual intracellular Ca2+ increases and successful oocyte activation, hinting at potential alternative mechanisms. In this review, we introduced the current hypothesis surrounding oocyte activation in mammals, informed by contemporary literature, and probed into the enigmatic mechanisms underlying mammalian fertilization-induced oocyte activation. |
|
言語 |
en |
| 書誌情報 |
Biomolecules
巻 14,
号 3,
p. 1-21,
発行日 2024-03-17
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| 出版者 |
|
|
出版者 |
MDPI |
| DOI |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.3390/biom14030359 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 査読 |
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|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
biomolecules-14-00359-v3.pdf (2.4 MB)
