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Chromatin structure in totipotent mouse early preimplantation embryos
https://az.repo.nii.ac.jp/records/2000194
https://az.repo.nii.ac.jp/records/20001940725433a-81ed-421f-b88c-5180040b242d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
70_2023-106.pdf (4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2024-12-13 | |||||||
| タイトル | ||||||||
| タイトル | Chromatin structure in totipotent mouse early preimplantation embryos | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 著者 |
Ooga, Masatoshi
× Ooga, Masatoshi
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| Abstract | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Totipotency refers to the ability of a single cell to give rise to all the different cell types in the body. Terminally differentiated germ cells (sperm and oocytes) undergo reprogramming, which results in the acquisition of totipotency in zygotes. Since the 1990s, numerous studies have focused on the mechanisms of totipotency. With the emergence of the concept of epigenetic reprogramming, which is important for the undifferentiated and differentiated states of cells, the epigenomes of germ cells and fertilized oocytes have been thoroughly analyzed. However, in early immunostaining studies, detailed epigenomic information was difficult to obtain. In recent years, the explosive development of next-generation sequencing has made it possible to acquire genome-wide information and the rise of genome editing has facilitated the analysis of knockout mice, which was previously difficult. In addition, live imaging can effectively analyze zygotes and 2-cell embryos, for which the number of samples is limited, and provides biological insights that cannot be obtained by other methods. In this review, the progress of our research using these advanced techniques is traced back from the present to its earliest years. | |||||||
| 言語 | en | |||||||
| 書誌情報 |
The Journal of reproduction and development 巻 70, 号 3, p. 152-159, 発行日 2024-03-08 |
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| 出版者 | ||||||||
| 出版者 | The Society for Reproduction and Development | |||||||
| DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1262/jrd.2023-106 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 査読 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 査読あり | |||||||
