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Neurophysiological Mechanisms Underlying the Attenuation of Nociceptive and Pathological Pain by Phytochemicals: Clinical Application as Therapeutic Agents
https://az.repo.nii.ac.jp/records/2000178
https://az.repo.nii.ac.jp/records/200017849804e1b-afae-47a4-aa5a-5d0af426182b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
M.Takeda, Progress in Neurobiology 11,1-13, 2024.pdf (828 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2024-11-29 | |||||||
| タイトル | ||||||||
| タイトル | Neurophysiological Mechanisms Underlying the Attenuation of Nociceptive and Pathological Pain by Phytochemicals: Clinical Application as Therapeutic Agents | |||||||
| 言語 | en | |||||||
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| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 著者 |
Takeda, Mamoru
× Takeda, Mamoru
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| Abstract | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Although phytochemicals are plant-derived toxins that are primarily produced by plants as a form of defense against insects or microbes, several lines of studies have demonstrated that phytochemicals (e.g., polyphenols, carotenoids, and amino acids) have several beneficial biological actions for human health, such as anti-oxidative, anti-inflammatory, and cardioprotective effects. Recent studies have demonstrated that phytochemicals can modulate neuronal excitability in the nervous system, including nociceptive sensory transmission, so it is possible that phytochemicals could be complementary alternative medicine candidates; specifically, therapeutic agents against pain. The focus of this review is to elucidate the mechanisms underlying the modulatory effects of phytochemicals on neuronal electrical signals, such as generator potentials, action potentials, and postsynaptic potentials, in the nociceptive pathway neurons resulting in potential local anesthetic effects, intravenous anesthesia and analgesic effects, and inflammatory pain relief effects. In addition, we discuss the contribution of phytochemicals to the relief of nociceptive and/or pathological pain and their potential clinical application on the basis of our recent studies in vivo. | |||||||
| 言語 | en | |||||||
| 書誌情報 |
Progress in Neurobiology 巻 11, p. 1-13, 発行日 2024-04 |
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| 出版者 | ||||||||
| 出版者 | Progress in Neurobiology | |||||||
| DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.60124/j.PNEURO.2024.10.02 | |||||||
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| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 査読 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 査読あり | |||||||
