2026-03-12T05:09:13Z https://az.repo.nii.ac.jp/oai

oai:az.repo.nii.ac.jp:00003737 2023-12-19T05:59:34Z 17:236:230 17:254:344 17:257:357 31:181:453

Association of paraoxonase 1 gene polymorphism with Intima-Media Thickness (IMT) of the carotid arteries in japanese type 2 diabetic patients Honda, Teruko Takada, Kayoko Maeda, Makiko Nonen, Sinpei Motomura, Takashi Maeda, Keiji Fujio, Yasushi Azuma, Junichi Yamamoto, Isamu \n paraoxonase 1 genetic polymorphism intima-media thickness (IMT) Purpose: We investigated the association between paraoxonase 1 (PON1)-192 genotypes and intimamedia thickness (IMT) of carotid arteries in diabetic patients. Methods: One hundred and fifty-five Japanese type 2 diabetic patients aged from 40 to 79 years were enrolled in this study. Genotypes of the patients were determined using the PCR-RFLP method. The IMT of carotid arteries of the subjects was measured by ultrasound imaging. Results: The PON1 genotypes frequencies were as follows: 18QQ (0.116), 70QR (0.452) and 67RR (0.432). IMT values of the RR group were significantly greater (1.08±0.41 mm, n=67) than those of the Q group, which consisted of patients carrying one or two Q alleles (0.95±0.27 mm, n=88, P=0.023). There were no significant difference in the clinical characteristics between the two groups. Conclusion: The results indicate that the PON1-192RR genotype is associated with intima media thickening of the carotid arteries in diabetic patients. P(論文) 40019736749 原著論文 application/pdf ORIGINAL ARTICLE departmental bulletin paper 麻布大学 Azabu University 2013-01-31 VoR VoR application/pdf 麻布大学雑誌 24 31 35 Journal of Azabu University 1346-5880 AA11561468 https://az.repo.nii.ac.jp/record/3737/files/bull_jau_vol24-031.pdf https://doi.org/10.14944/00003716 https://az.repo.nii.ac.jp/records/3737 eng