2026-03-15T08:06:38Z https://az.repo.nii.ac.jp/oai

oai:az.repo.nii.ac.jp:02000373 2025-03-06T06:40:05Z 423

Serum concentration and safety of intravenous drip versus subcutaneous administration of carboplatin in dogs Iwano, Masataka Iwano Masataka Sadahiro, Kohei Sadahiro Kohei Maruo, Takuya Maruo Takuya Kawarai, Shinpei Kawarai Shinpei Kayanuma, Hideki Kayanuma Hideki Orito, Kensuke Orito Kensuke Carboplatin is used to treat certain cancers in dogs and cats and is routinely administered via intravenous drip (IVD). Subcutaneous (SC) administration has also been described. However, the toxicity, serum concentrations, and area under blood concentration-time curves (AUCs) of SC carboplatin are unknown. This study aimed to compare serum carboplatin concentrations in dogs after SC and IVD and to monitor any adverse events. In this crossover study, five dogs received SC or IV carboplatin (300 mg/m2). After a minimum of 3 weeks, each dog received the other treatment. No gross skin toxicity or abnormal clinical signs were observed in any of the dogs. Blood test abnormalities were detected in most dogs. Decreased neutrophil and platelet counts, and increased C-reactive protein (CRP) levels were found. There was no significant difference in the neutropenia, thrombocytopenia, and CRP scores between the groups. Systemic toxicities of SC carboplatin were comparable to those of IVD carboplatin. The time to maximum carboplatin concentration after SC was longer than that after IVD (P<0.001). SC carboplatin remained in the serum longer than IVD carboplatin (P=0.008). The AUC of SC was less than that of IVD (P=0.002). The AUC and time taken to reach the maximum concentration of SC carboplatin were lower than those of IVD carboplatin. This study suggests that SC carboplatin may be an efficacious option for the treatment of tumors in dogs, particularly where IVD administration is challenging. The Japanese Society of Veterinary Science 2021-05-09 eng journal article VoR https://az.repo.nii.ac.jp/records/2000373 10.1292/jvms.20-0653 The Journal of Veterinary Medical Science 83 5 775 779 https://az.repo.nii.ac.jp/record/2000373/files/83_20-0653.pdf application/pdf 822 KB 2025-03-06