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ラット周生期における動脈管調節因子の発現動態とその機能
https://az.repo.nii.ac.jp/records/5039
https://az.repo.nii.ac.jp/records/5039ca416617-07f0-4091-baa1-250a25322fad
名前 / ファイル | ライセンス | アクション |
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bull_jau_vol15-16-161.pdf (245.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-01-01 | |||||
タイトル | ||||||
タイトル | ラット周生期における動脈管調節因子の発現動態とその機能 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Characterization of regulators of ductus arteriosus tone in the perinatal rat | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
記事種別 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 特集 | |||||
Type | ||||||
内容記述タイプ | Other | |||||
内容記述 | FEATURE ARTICLES | |||||
著者 |
有嶋, 和義
× 有嶋, 和義× 山本, 雅子× 白井, 明志× Arishima, Kazuyoshi× Yamamoto, Masako× Shirai, Mitsuyuki |
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著者ID | ||||||
000047 | ||||||
著者ID | ||||||
000059 | ||||||
著者ID | ||||||
000230 | ||||||
Author ID | ||||||
000047 | ||||||
Author ID | ||||||
000059 | ||||||
Author ID | ||||||
000230 | ||||||
所属機関 | ||||||
麻布大学大学院獣医学研究科 | ||||||
所属機関 | ||||||
麻布大学大学院獣医学研究科 | ||||||
所属機関 | ||||||
麻布大学大学院獣医学研究科 | ||||||
Institution or Company | ||||||
Graduate School of Veterinary Science, Azabu University | ||||||
Institution or Company | ||||||
Graduate School of Veterinary Science, Azabu University | ||||||
Institution or Company | ||||||
Graduate School of Veterinary Science, Azabu University | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 選択的COX-1阻害薬piroxicamと選択的COX-2阻害薬etodolacのラット胎子動脈管に及ぼす影響について検討した。Piroxicamおよびetodolacにおいて,用量依存的に胎子動脈管は収縮した。一方,免疫組織学的に,動脈管におけるCOX-1およびCOX-2の局在を検索してみたが,その局在を確認することができなかった。本研究では,動脈管におけるCOX-1およびCOX-2の局在を明らかにできなかったが,COX-1あるいはCOX-2のどちらかのCOXのアイソフォームが阻害されても胎子動脈管が収縮することが示され,これらの両方のアイソフォームがともに動脈管の調節に機能していることが示唆された。 | |||||
Abstract | ||||||
内容記述タイプ | Other | |||||
内容記述 | Constrictive effect of a selective cyclooxygenase (COX)-l inhibitor, piroxicam, and a selective COX-2 inhibitor, etdolac, on the ducts arteriosus (DA) was investigated in the rat. Rats were given piroxicam (10, 30, 100 mg/kg) or etodlac (10, 30, 100 mg/kg) on day 21 of pregnancy, and fetal ductus arteriosus (DA) was studied with a whole-body freezing method. All proxicam-treated groups and the 30 mg/kg and 100 mg/kg etodolac-treated groups showed a significant constriction of the DA 3 hours dose-dependently after maternal each COX inhibitor treatment. These results indicate that both COX-1 and COX-2 selective inhibitor induce constriction of the fetal DA in a dose-dependent manner as well as non-selective COX inhibitors when administered in late stage of gestation and that both COX-1 and COX-2 regulate doctus arteriosus tone in the fetal rat. | |||||
書誌情報 |
麻布大学雑誌 en : Journal of Azabu University 巻 15/16, p. 161-163, 発行日 2008-03-31 |
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出版者 | ||||||
出版者 | 麻布大学 | |||||
Publisher | ||||||
出版者 | Azabu University | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1346-5880 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11561527 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
text version | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
format | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |