WEKO3
アイテム
{"_buckets": {"deposit": "13bc1ef6-22e6-4dee-b353-26db64bd17d9"}, "_deposit": {"created_by": 4, "id": "4678", "owners": [4], "pid": {"revision_id": 0, "type": "depid", "value": "4678"}, "status": "published"}, "_oai": {"id": "oai:az.repo.nii.ac.jp:00004678", "sets": ["334", "490"]}, "author_link": ["20346", "20345"], "item_12_biblio_info_16": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-03-31", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "190", "bibliographicPageStart": "188", "bibliographicVolumeNumber": "9/10", "bibliographic_titles": [{"bibliographic_title": "麻布大学雑誌"}, {"bibliographic_title": "Journal of Azabu University", "bibliographic_titleLang": "en"}]}]}, "item_12_description_13": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "近年,免疫介在性溶血性貧血,血小板減少症,あるいは骨髄線維症などの免疫介在疾患の犬に対して,ヒトの免疫グロブリン(h-IVIG)療法が用いられるようになっている。この治療法の主な副作用として,血栓症の発現が危惧されているが,それについての詳細な検討は行われていない。そこで我々は,実験的にIVIGを投与した犬の凝固系検査と血小板凝集試験を実施して,本療法による血栓症発現リスクについて検討した。2頭のビーグル犬にヒトIgG製剤を1g/kg静脈内投与した。その結果,2頭に共通して,末梢血の白血球数と血小板数は投与開始2~4時間後に減少し,その後も数日間持続した。フィブリン/フィリノーゲン分解産物も,IVIG投与開始8時間後から24時間後にかけて増加した。また,1頭において顕著なフィブリノーゲン濃度の増加が認められた。さらに血小板凝集試験の結果,ADP刺激ではIVIG投与開始2時間後から24時間後にかけて,またPAF刺激では投与開始2時間後に,顕著な凝集活性の低下が認められた。以上の結果から,IVIG療法による血栓症発現のリスクは,予想以上に高いものと思われた。", "subitem_description_type": "Abstract"}]}, "item_12_description_14": {"attribute_name": "Abstract", "attribute_value_mlt": [{"subitem_description": "Intravenous human immunoglobulin (h-IVIG) therapy is currently used for dogs with immunemediated diseases including hemolytic anemia, thrombocytopenia and bone marrow fibrosis. The most important potential adverse effect of this therapy is thromboembolism; however, this risk has not previously been evaluated in dogs. Therefore, we experimentally investigated changes of the complete blood cell counts, coagulation parameters and platelet aggregation in dogs that were administered h-IVIG. Human immunoglobulin G 1g/kg was infused intravenously for 8 hours in two dogs. Leukopenia and thrombocytopenia occurred in both the dogs 2-4 hours after starting the infusion and these changes persisted for several days. Fibrin/fibrinogen degradation products were increased 8 and 24 hours after starting the infusion. Plasma fibrinogen concentration increased in one of the dogs given h-IVIG. ADP-induced platelet aggregation was decreased 2 to 24 hours after starting the infusion compared to baseline studies. PAF-induced aggregation was also decreased relative to baseline 2 hours after staring the infusion. These results suggest a much higher risk of embolism than had been expected.", "subitem_description_type": "Other"}]}, "item_12_description_2": {"attribute_name": "ページ属性", "attribute_value_mlt": [{"subitem_description": "P(論文)", "subitem_description_type": "Other"}]}, "item_12_description_3": {"attribute_name": "記事種別", "attribute_value_mlt": [{"subitem_description": "特集", "subitem_description_type": "Other"}]}, "item_12_description_34": {"attribute_name": "format", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_12_description_4": {"attribute_name": "Type", "attribute_value_mlt": [{"subitem_description": "FEATURE ARTICLES", "subitem_description_type": "Other"}]}, "item_12_publisher_19": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "麻布大学"}]}, "item_12_publisher_20": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_publisher": "Azabu University"}]}, "item_12_source_id_21": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1346-5880", "subitem_source_identifier_type": "ISSN"}]}, "item_12_source_id_23": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11561468", "subitem_source_identifier_type": "NCID"}]}, "item_12_text_10": {"attribute_name": "Author ID", "attribute_value_mlt": [{"subitem_text_value": "000071"}]}, "item_12_text_11": {"attribute_name": "所属機関", "attribute_value_mlt": [{"subitem_text_value": "麻布大学獣医学部"}]}, "item_12_text_12": {"attribute_name": "Institution or Company", "attribute_value_mlt": [{"subitem_text_value": "School of Veterinary Medicine, Azabu University"}]}, "item_12_text_9": {"attribute_name": "著者ID", "attribute_value_mlt": [{"subitem_text_value": "000071"}]}, "item_12_version_type_29": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_12_version_type_30": {"attribute_name": "text version", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "土屋, 亮"}, {"creatorName": "ツチヤ, リョウ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "20345", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuchiya, Ryo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "20346", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2004-01-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "bull_jau_vol9-10-188.pdf", "filesize": [{"value": "239.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 239800.0, "url": {"label": "bull_jau_vol9-10-188.pdf", "url": "https://az.repo.nii.ac.jp/record/4678/files/bull_jau_vol9-10-188.pdf"}, "version_id": "b5f9c97b-8d1f-4cc5-9689-3d783d4e7fc2"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "イヌの免疫介在性血小板減少症に対するIgG大量静注(IVIG)療法の検討", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "イヌの免疫介在性血小板減少症に対するIgG大量静注(IVIG)療法の検討"}, {"subitem_title": "Study of intravenous IgG therapy for dogs with immune-mediated thrombocytopenia", "subitem_title_language": "en"}]}, "item_type_id": "12", "owner": "4", "path": ["334", "490"], "permalink_uri": "https://az.repo.nii.ac.jp/records/4678", "pubdate": {"attribute_name": "公開日", "attribute_value": "2004-01-01"}, "publish_date": "2004-01-01", "publish_status": "0", "recid": "4678", "relation": {}, "relation_version_is_last": true, "title": ["イヌの免疫介在性血小板減少症に対するIgG大量静注(IVIG)療法の検討"], "weko_shared_id": 4}
イヌの免疫介在性血小板減少症に対するIgG大量静注(IVIG)療法の検討
https://az.repo.nii.ac.jp/records/4678
https://az.repo.nii.ac.jp/records/4678c1abac20-954e-49de-8d20-1b0fb739310f
名前 / ファイル | ライセンス | アクション |
---|---|---|
bull_jau_vol9-10-188.pdf (239.8 kB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2004-01-01 | |||||
タイトル | ||||||
タイトル | イヌの免疫介在性血小板減少症に対するIgG大量静注(IVIG)療法の検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Study of intravenous IgG therapy for dogs with immune-mediated thrombocytopenia | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
記事種別 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 特集 | |||||
Type | ||||||
内容記述タイプ | Other | |||||
内容記述 | FEATURE ARTICLES | |||||
著者 |
土屋, 亮
× 土屋, 亮× Tsuchiya, Ryo |
|||||
著者ID | ||||||
000071 | ||||||
Author ID | ||||||
000071 | ||||||
所属機関 | ||||||
麻布大学獣医学部 | ||||||
Institution or Company | ||||||
School of Veterinary Medicine, Azabu University | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 近年,免疫介在性溶血性貧血,血小板減少症,あるいは骨髄線維症などの免疫介在疾患の犬に対して,ヒトの免疫グロブリン(h-IVIG)療法が用いられるようになっている。この治療法の主な副作用として,血栓症の発現が危惧されているが,それについての詳細な検討は行われていない。そこで我々は,実験的にIVIGを投与した犬の凝固系検査と血小板凝集試験を実施して,本療法による血栓症発現リスクについて検討した。2頭のビーグル犬にヒトIgG製剤を1g/kg静脈内投与した。その結果,2頭に共通して,末梢血の白血球数と血小板数は投与開始2~4時間後に減少し,その後も数日間持続した。フィブリン/フィリノーゲン分解産物も,IVIG投与開始8時間後から24時間後にかけて増加した。また,1頭において顕著なフィブリノーゲン濃度の増加が認められた。さらに血小板凝集試験の結果,ADP刺激ではIVIG投与開始2時間後から24時間後にかけて,またPAF刺激では投与開始2時間後に,顕著な凝集活性の低下が認められた。以上の結果から,IVIG療法による血栓症発現のリスクは,予想以上に高いものと思われた。 | |||||
Abstract | ||||||
内容記述タイプ | Other | |||||
内容記述 | Intravenous human immunoglobulin (h-IVIG) therapy is currently used for dogs with immunemediated diseases including hemolytic anemia, thrombocytopenia and bone marrow fibrosis. The most important potential adverse effect of this therapy is thromboembolism; however, this risk has not previously been evaluated in dogs. Therefore, we experimentally investigated changes of the complete blood cell counts, coagulation parameters and platelet aggregation in dogs that were administered h-IVIG. Human immunoglobulin G 1g/kg was infused intravenously for 8 hours in two dogs. Leukopenia and thrombocytopenia occurred in both the dogs 2-4 hours after starting the infusion and these changes persisted for several days. Fibrin/fibrinogen degradation products were increased 8 and 24 hours after starting the infusion. Plasma fibrinogen concentration increased in one of the dogs given h-IVIG. ADP-induced platelet aggregation was decreased 2 to 24 hours after starting the infusion compared to baseline studies. PAF-induced aggregation was also decreased relative to baseline 2 hours after staring the infusion. These results suggest a much higher risk of embolism than had been expected. | |||||
書誌情報 |
麻布大学雑誌 en : Journal of Azabu University 巻 9/10, p. 188-190, 発行日 2005-03-31 |
|||||
出版者 | ||||||
出版者 | 麻布大学 | |||||
Publisher | ||||||
出版者 | Azabu University | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1346-5880 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11561468 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
text version | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
format | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |