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マスト細胞活性化機構の解析を中心としたアレルギー疾患に及ぼすコプラナーPCBsの影響
https://az.repo.nii.ac.jp/records/4457
https://az.repo.nii.ac.jp/records/445796e0784c-eedb-4612-aa78-760245a60391
名前 / ファイル | ライセンス | アクション |
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bull_jau_vol5-6-213.pdf (100.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2002-01-01 | |||||
タイトル | ||||||
タイトル | マスト細胞活性化機構の解析を中心としたアレルギー疾患に及ぼすコプラナーPCBsの影響 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The effects of Co-PCBs in allergic disorder : Analyses of mast cell functions in response to Co-PCBs.(Research Group 5) | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
記事種別 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 特集 | |||||
Type | ||||||
内容記述タイプ | Other | |||||
内容記述 | FEATURE ARTICLES | |||||
著者 |
池田, 輝雄
× 池田, 輝雄× 舟場, 正幸× Ikeda, Teruo× Funaba, Masayuki |
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著者ID | ||||||
000065 | ||||||
著者ID | ||||||
- | ||||||
Author ID | ||||||
000065 | ||||||
Author ID | ||||||
- | ||||||
所属機関 | ||||||
麻布大学獣医学部 | ||||||
所属機関 | ||||||
麻布大学獣医学部 | ||||||
Institution or Company | ||||||
School of Veterinary Medicine, Azabu University | ||||||
Institution or Company | ||||||
School of Veterinary Medicine, Azabu University | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | マスト細胞におけるAhRシグナリング関連分子のmRNAの発現とCo-PCBsの影響を検討した。マスト細胞株のうちRBL-2H3とIC-2,初代培養マスト細胞(BMCMCs)がAhRとARNTのmRNAを発現していた。またレポーターアッセイのレシピエントとしてよく知られているRaw294およびCHO-K1はいずれのmRNAも発現していなかった。陽性対照として使用したTCDDおよびCo-PCBsのいずれの濃度でもマスト細胞の脱顆粒およびTNF-αの放出に影響しなかった。これらの結果は,マスト細胞がCo-PCBsのターゲット細胞ではあるが,脱顆粒およびTNF-αの放出が介在した免疫反応には直接影響しないことを示唆している。 | |||||
Abstract | ||||||
内容記述タイプ | Other | |||||
内容記述 | In this study, we examined the gene expression of molecules involved in AhR signaling and the effects of Co-PCBs in mast cell. The niRNA expression of AhR and ARNT was detected in RBL-2H3, IC-2 and Bone marrow derived cultured mast cell (BMCMCs). Raw 294 and CHO-K1 known as recipient cell in reporter assay, were not expressed both mRNAs. Any concentrations of Co-PCBs and TCDD as control did not affected degranulation and TNF-a release in both of RBL-2H3 and BMCMCs. These results suggest that mast cells are the targets of Co-PCBs, but Co-PCBs does not involved directly immune-response through both degranulation and TNA-a release in mast cells. | |||||
書誌情報 |
麻布大学雑誌 en : Journal of Azabu University 巻 5/6, p. 213-214, 発行日 2003-03-31 |
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レポート・演題番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 麻布大学ハイテク・リサーチ・センター研究プロジェクト 研究サブ・グループ5 | |||||
出版者 | ||||||
出版者 | 麻布大学 | |||||
Publisher | ||||||
出版者 | Azabu University | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1346-5880 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11561468 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
text version | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
format | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |