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イヌの免疫介在性血小板減少症に対するヒトIgG大量静注療法の検討
https://az.repo.nii.ac.jp/records/4443
https://az.repo.nii.ac.jp/records/4443975a5786-04c1-476a-94f2-23e43610b19d
名前 / ファイル | ライセンス | アクション |
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bull_jau_vol5-6-166.pdf (255.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2002-01-01 | |||||
タイトル | ||||||
タイトル | イヌの免疫介在性血小板減少症に対するヒトIgG大量静注療法の検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Study of intra-venous human immunogrobulin therapy in dogs with immune-mediated thrombocytopenia | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
記事種別 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 特集 | |||||
Type | ||||||
内容記述タイプ | Other | |||||
内容記述 | FEATURE ARTICLES | |||||
著者 |
土屋, 亮
× 土屋, 亮× 久末, 正晴× 山田, 隆紹× Tsuchiya, Ryo× Hisasue, Masaharu× Yamada, Takatsugu |
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著者ID | ||||||
000071 | ||||||
著者ID | ||||||
000317 | ||||||
著者ID | ||||||
- | ||||||
Author ID | ||||||
000071 | ||||||
Author ID | ||||||
000317 | ||||||
Author ID | ||||||
- | ||||||
所属機関 | ||||||
麻布大学大学院獣医学研究科 | ||||||
所属機関 | ||||||
麻布大学獣医学部 | ||||||
所属機関 | ||||||
麻布大学大学院獣医学研究科 | ||||||
Institution or Company | ||||||
Graduate School of Veterinary Science, Azabu University | ||||||
Institution or Company | ||||||
SchooI of Veterinary Medicine, Azabu University | ||||||
Institution or Company | ||||||
Graduate School of Veterinary Science, Azabu University | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 近年,イヌの原発性IMPや免疫介在性溶血性貧血症例に対してヒトのIgG製剤の投与が試みられ,劇的な効果が得られている。この効果機序を調べるために,熱凝集イヌIgG(HAIgG)の類粒球への結合に対する,ヒトIgG製剤の阻害効果を検討した。0.5μgから4μgのHAIgGの結合に対して,それぞれ50倍濃度のヒトlgGを作用させたところ,HAIgG濃度2μg,ヒトIgGlOOμg/120μlにおいて最も強い阻害効果が認められた。 以上の結果から,イヌの免疫介在性血小板減少症に対して用いられているヒトIgG大量静注療法の効果が,IgG Fcリセプターを介した細内系食細胞による血小板貪食の競合的阻害によることが示唆された。 |
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Abstract | ||||||
内容記述タイプ | Other | |||||
内容記述 | Human intravenous Ig has been used successfully in the treatment of immune-mediated diseases including thrombocytopenia and anemia in dogs. The inhibitive effect of human immunoglobulinG (h-IgG) on the binding of heat-aggregated IgG to canine granulocytes was investigated. Co-incubation with a 50-hold excess of h-IgG inhibited binding and the greatest effect was obtained at 100μg/120μl of h-IgG and 2μg of heat-aggregated IgG. The results obtained support the therapeutic rationale of administration of h-IgG intravenous infusion to dogs with immune-mediated diseases by demonstrating blockage of the IgG Fc receptor on cells which possess the same IgG Fc receptor as cells of the mononuclear phagocyte system. | |||||
書誌情報 |
麻布大学雑誌 en : Journal of Azabu University 巻 5/6, p. 166-168, 発行日 2003-03-31 |
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出版者 | ||||||
出版者 | 麻布大学 | |||||
Publisher | ||||||
出版者 | Azabu University | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1346-5880 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11561468 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
text version | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
format | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |