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ラット周生期における動脈管調節因子の発現動態とその機能
https://az.repo.nii.ac.jp/records/3915
https://az.repo.nii.ac.jp/records/391524fd9532-9510-4b89-a7d8-e11fb8aa95f3
名前 / ファイル | ライセンス | アクション |
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bull_jau_vol17-18-177 (249.8 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2014-02-21 | |||||
タイトル | ||||||
タイトル | ラット周生期における動脈管調節因子の発現動態とその機能 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Characterization of regulators of ductus arteriosus tone in the perinatal rat | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
記事種別 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 特集 | |||||
Type | ||||||
内容記述タイプ | Other | |||||
内容記述 | FEATURE ARTICLES | |||||
著者 |
有嶋, 和義
× 有嶋, 和義× 山本, 雅子× 白井, 明志× Arishima, Kazuyoshi× Yamamoto, Masako× Shirai, Mitsuyuki |
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著者ID | ||||||
000047 | ||||||
著者ID | ||||||
000059 | ||||||
著者ID | ||||||
000230 | ||||||
Author ID | ||||||
000047 | ||||||
Author ID | ||||||
000059 | ||||||
Author ID | ||||||
000230 | ||||||
所属機関 | ||||||
麻布大学大学院獣医学研究科 | ||||||
所属機関 | ||||||
麻布大学大学院獣医学研究科 | ||||||
所属機関 | ||||||
麻布大学大学院獣医学研究科 | ||||||
Institution or Company | ||||||
Graduate School of Veterinary Science,Azabu University | ||||||
Institution or Company | ||||||
Graduate School of Veterinary Science,Azabu University | ||||||
Institution or Company | ||||||
Graduate School of Veterinary Science,Azabu University | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 胎子動脈管の母体indomethacin投与による収縮から再び拡張するまでの回復過程におけるNOの関与を検討するために,indomethacinによる収縮が最も強く発現するindomethacin (1 and 10 mg/kg) 投与後3時間にNO合成酵素 (NOS) 阻害剤であるN(G)-nitro-L-arginine methyl ester (L-NAME; 50 mg/kg) を投与しその後の動脈管の変化を観察した。 妊娠20日の母ラットにindomethacinを投与し,その3時間後にL-NAMEを投与すると,その子の動脈管はindomethacinの投与後24時間 (L-NAMEの投与後21時間) において,対照群と比較して有意な低値を示し,動脈管は収縮していた。観察された胎子動脈管の収縮の程度は,indomethacin投与後3時間でみられた収縮とほぼ同等であり,indomethacinによる収縮が持続し再拡張過程にはないことが明らかとなった。 以上のとおり,胎子動脈管の母体indomethacin投与による収縮から再び拡張するまでの回復過程におおいてNOのが重要な役割を担っていることが示唆された。 |
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Abstract | ||||||
内容記述タイプ | Other | |||||
内容記述 | We studied the effects of N(G)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase inhibitor, on the ductus arteriosus (DA) that constricted by maternal indomethacin administration in fetal rat. Pregnant rats were administered indomethacin (1 and 10 mg/kg) orally 24 hr before cesarean section, and then L-NAME (50 mg/kg) was injected intraperitoneally 3 hr after indomethacin administration. The caliber of the fetal DA was studied with a whole-body freezing method. Indomethacin alone group showed that the fetal DA was reopened 24 h after maternal indomethacin administration. However, compared with the indomethacin alone group, L-NAME-treated group showed a significant constriction of the DA 24 h after maternal indomethacin administration. These results indicate that NO has a significant role in the course of reopening of the fetal DA that constricted by maternal indomethacin administration. |
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書誌情報 |
麻布大学雑誌 en : Journal of Azabu University 巻 17/18, p. 177-179, 発行日 2009-03-31 |
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出版者 | ||||||
出版者 | 麻布大学 | |||||
Publisher | ||||||
出版者 | Azabu University | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1346-5880 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11561468 | |||||
NII論文ID(NAID) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 40016759585 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
text version | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
format | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |